{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:57:51Z","timestamp":1785196671491,"version":"3.55.0"},"reference-count":29,"publisher":"The Royal Society","issue":"2021","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["095831"],"award-info":[{"award-number":["095831"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"crossref","award":["NE\/I024038\/1"],"award-info":[{"award-number":["NE\/I024038\/1"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"crossref","award":["NE\/I026367\/1"],"award-info":[{"award-number":["NE\/I026367\/1"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:p>\n                    Within-host interactions among coinfecting parasites can have major consequences for individual infection risk and disease severity. However, the impact of these within-host interactions on between-host parasite transmission, and the spatial scales over which they occur, remain unknown. We developed and apply a novel spatially explicit analysis to parasite infection data from a wild wood mouse (\n                    <jats:italic>Apodemus sylvaticus<\/jats:italic>\n                    ) population. We previously demonstrated a strong within-host negative interaction between two wood mouse gastrointestinal parasites, the nematode\n                    <jats:italic>Heligmosomoides polygyrus<\/jats:italic>\n                    and the coccidian\n                    <jats:italic>Eimeria hungaryensis<\/jats:italic>\n                    , using drug-treatment experiments. Here, we show this negative within-host interaction can significantly alter the between-host transmission dynamics of\n                    <jats:italic>E. hungaryensis<\/jats:italic>\n                    , but only within spatially restricted neighbourhoods around each host. However, for the closely related species\n                    <jats:italic>E. apionodes<\/jats:italic>\n                    , which experiments show does not interact strongly with\n                    <jats:italic>H. polygyrus<\/jats:italic>\n                    , we did not find any effect on transmission over any spatial scale. Our results demonstrate that the effects of within-host coinfection interactions can ripple out beyond each host to alter the transmission dynamics of the parasites, but only over local scales that likely reflect the spatial dimension of transmission. Hence there may be knock-on consequences of drug treatments impacting the transmission of non-target parasites, altering infection risks even for non-treated individuals in the wider neighbourhood.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2024.0103","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T03:06:50Z","timestamp":1713323210000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of within-host coinfection interactions on between-host parasite transmission dynamics varies with spatial scale"],"prefix":"10.1098","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-4408","authenticated-orcid":true,"given":"Shaun P.","family":"Keegan","sequence":"first","affiliation":[{"name":"Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7ZB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-1360","authenticated-orcid":true,"given":"Amy B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7676-917X","authenticated-orcid":true,"given":"Andy","family":"Fenton","sequence":"additional","affiliation":[{"name":"Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7ZB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200001698X"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02490"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/656496"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.0598"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00284.x"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/321909"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.07.005"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2006.11.005"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200700025X"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-157"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013000590"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261714"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2014.03.001"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2013.0205"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182019000192"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2018.04.003"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijppaw.2019.03.004"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2656.2005.00966.x"},{"key":"e_1_3_8_20_2","first-page":"287","volume-title":"The biology of the coccidia","author":"Fernando MA","year":"1982","unstructured":"Fernando MA. 1982 Pathology and pathogenicity. In The biology of the coccidia (ed. PL Long), pp. 287-327. London, UK: Edward Arnold."},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005545"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90059-K"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(94)90181-3"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000075855"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1515\/9781400840809"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.06.005"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.2286"},{"key":"e_1_3_8_28_2","doi-asserted-by":"crossref","unstructured":"Keegan SP Pedersen AB Fenton A. 2024 Data from: The impact of within-host coinfection interactions on between-host parasite transmission dynamics varies with spatial scale. Dryad Digital Repository. 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