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R. Soc. B."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n            The WHO aims to eliminate schistosomiasis as a public health problem by 2030. However, standard morbidity measures poorly correlate to infection intensities, hindering disease monitoring and evaluation. This is exacerbated by insufficient evidence on\n            <jats:italic>Schistosoma<\/jats:italic>\n            \u2019s impact on health-related quality of life (HRQoL). We conducted community-based cross-sectional surveys and parasitological examinations in moderate-to-high\n            <jats:italic>Schistosoma mansoni<\/jats:italic>\n            endemic communities in Uganda. We calculated parasitic infections and used EQ-5D instruments to estimate and compare HRQoL utilities in these populations. We further employed Tobit\/linear regression models to predict HRQoL determinants. Two-thirds of the 560 participants were diagnosed with parasitic infection(s), 49% having\n            <jats:italic>S. mansoni<\/jats:italic>\n            . No significant negative association was observed between HRQoL and\n            <jats:italic>S. mansoni<\/jats:italic>\n            infection status\/intensity. However, severity of pain urinating (\n            <jats:italic>\u03b2<\/jats:italic>\n            = \u22120.106; s.e. = 0.043) and body swelling (\n            <jats:italic>\u03b2<\/jats:italic>\n            = \u22120.326; s.e. = 0.005), increasing age (\n            <jats:italic>\u03b2<\/jats:italic>\n            = \u22120.016; s.e. = 0.033), reduced socio-economic status (\n            <jats:italic>\u03b2<\/jats:italic>\n            = 0.128; s.e. = 0.032), and being unemployed predicted lower HRQoL. Symptom severity and socio-economic status were better predictors of short-term HRQoL than current\n            <jats:italic>S. mansoni<\/jats:italic>\n            infection status\/intensity. This is key to disentangling the link between infection(s) and short-term health outcomes, and highlights the complexity of correlating current infection(s) with long-term morbidity. Further evidence is needed on long-term schistosomiasis-associated HRQoL, health and economic outcomes to inform the case for upfront investments in schistosomiasis interventions.\n          <\/jats:p>","DOI":"10.1098\/rspb.2024.0449","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:57:42Z","timestamp":1718186262000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The short-term impact of\n            <i>Schistosoma mansoni<\/i>\n            infection on health-related quality of life: implications for current elimination policies"],"prefix":"10.1098","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6664-3736","authenticated-orcid":true,"given":"Sergi","family":"Alonso","sequence":"first","affiliation":[{"name":"School of Biodiversity, One Health and Veterinary Medicine &amp; Wellcome Centre for Integrative Parasitology, University of Glasgow , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Vector Borne and Neglected Tropical Diseases Control Division, Ministry of Health , Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Atuhaire","sequence":"additional","affiliation":[{"name":"Vector Borne and Neglected Tropical Diseases Control Division, Ministry of Health , Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrina Barungi","family":"Nankasi","sequence":"additional","affiliation":[{"name":"Vector Borne and Neglected Tropical Diseases Control Division, Ministry of Health , Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-5931","authenticated-orcid":true,"given":"Joaqu\u00edn M.","family":"Prada","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Faculty of Health &amp; Medical Sciences, University of Surrey , Guildford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6340-3083","authenticated-orcid":true,"given":"Emma","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Health Economics and Health Technology Assessment, School of Health &amp; Wellbeing, University of Glasgow , Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-6318","authenticated-orcid":true,"given":"Poppy H. 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