{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:46:17Z","timestamp":1783457177451,"version":"3.55.0"},"reference-count":54,"publisher":"The Royal Society","issue":"2036","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inception"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pasteur-Paris University International Doctoral Programme"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    In malaria-endemic regions,\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    and\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    coexist and may interact. For instance, fevers induced by\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    might activate dormant\n                    <jats:italic>P. vivax<\/jats:italic>\n                    parasites and concurrent radical cure of both species has been proposed to prevent relapses. Heterogeneous mosquito exposure may contribute to the dependence of both parasites. We conducted a literature review on their respective prevalence and that of co-infections. The data revealed a positive correlation between\n                    <jats:italic>P. vivax<\/jats:italic>\n                    and\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    prevalence, and co-infection prevalences exceeding expectations assuming infections occur independently. We used the review data to fit a compartmental model of co-infections that features heterogenous mosquito exposure. The fit suggests that heterogeneous exposure sufficiently explains the observed departure from independence. Finally, we performed simulations under the model assessing the impact on\n                    <jats:italic>P. vivax<\/jats:italic>\n                    prevalence of the activation-by-fever hypothesis and the radical cure proposition. We demonstrated a moderate impact of allowing\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    fevers to reactivate\n                    <jats:italic>P. vivax<\/jats:italic>\n                    and a substantial impact of treating\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    cases with radical cure. Our model highlights dependence between\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    and\n                    <jats:italic>P. vivax<\/jats:italic>\n                    and emphasizes the influence of heterogeneous mosquito exposure. This simple framework can inform the design of more complex models assessing integrated malaria control strategies in coendemic regions.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2024.2061","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T19:05:58Z","timestamp":1733252758000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Heterogeneous mosquito exposure increases\n                    <i>Plasmodium vivax<\/i>\n                    and\n                    <i>Plasmodium falciparum<\/i>\n                    co-infections: a modelling study"],"prefix":"10.1098","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5781-0536","authenticated-orcid":true,"given":"Mathilde","family":"Grim\u00e9e","sequence":"first","affiliation":[{"name":"Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]},{"name":"Sorbonne Universit\u00e9, Coll\u00e8ge doctoral","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"White","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0141"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70177-X"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.64.97"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-253"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080227"},{"key":"e_1_3_8_7_2","volume-title":"Studies in the parasitology of malaria","author":"Knowles R","year":"1930","unstructured":"Knowles R, White RS. 1930 Studies in the parasitology of malaria. 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