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B."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Some selfish genetic elements drive at meiosis to achieve transmission distortion, breaking the rules of Mendelian segregation to enhance their own evolutionary success. It has been shown that enhancers of drive must act in\n                    <jats:italic toggle=\"yes\">cis<\/jats:italic>\n                    in order to gain the selfish benefit of drive and that suppressors of drive will be selected at unlinked loci. Here, we model the evolution of an autosomal\n                    <jats:italic toggle=\"yes\">trans<\/jats:italic>\n                    -acting gene (\n                    <jats:italic toggle=\"yes\">Distorter<\/jats:italic>\n                    ) that causes the Y chromosome (or even 0 chromosome) to drive without driving itself, a phenomenon we call \u2018remote-control meiotic drive\u2019. We show that such a gene may spread in the population when linked to a second locus,\n                    <jats:italic toggle=\"yes\">Assister<\/jats:italic>\n                    , whose alleles are transmitted at different frequencies through sperm as compared to eggs, for which we consider various scenarios, such as sexually antagonistic selection or sex-limited drive. Depending on the mechanistic details of sex-chromosome drive,\n                    <jats:italic toggle=\"yes\">Distorter<\/jats:italic>\n                    \u2019s spread can additionally facilitate transitions between XY and X0 sex determination. Our results provide a proof of principle that stretches the current understanding of segregation modifier and sex allocation theory. Moreover, we identify alternative evolutionary trajectories that could also lead to remote control drive and discuss its potential applications in developing synthetic sex-ratio-distorting elements for use in pest management, for example.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2025.1085","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T23:06:36Z","timestamp":1756249596000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Autosomally-encoded segregation distortion of sex chromosomes"],"prefix":"10.1098","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6880-4562","authenticated-orcid":true,"given":"Naomi L.","family":"Greenberg","sequence":"first","affiliation":[{"name":"Department of Biology, Georgetown University","place":["Washington, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-7977","authenticated-orcid":true,"given":"Manus M.","family":"Patten","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University","place":["Washington, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-319X","authenticated-orcid":true,"given":"Martijn A.","family":"Schenkel","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University","place":["Washington, USA"]},{"name":"Groningen Institute for Evolutionary Life Sciences, University of Groningen","place":["Groningen, The Netherlands"]},{"name":"Institute of Organismic and Molecular Evolution, Johannes Gutenberg Universitat Mainz","place":["Mainz, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5962\/bhl.title.61004","volume-title":"Versuche \u00fcber pflanzen-hybriden, verhandelungen der naturforschenden verein von br\u00fcnn","author":"Mendel GJ","year":"1866","unstructured":"Mendel GJ. 1866 Versuche \u00fcber pflanzen-hybriden, verhandelungen der naturforschenden verein von br\u00fcnn, pp. 3\u201347, vol. 4. 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