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R. Soc. B."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    Light pollution is a major anthropogenic environmental change and a significant threat to ecosystems. Among other detrimental effects on physiology, artificial light at night (ALAN) disrupts circadian rhythms in a wide range of species. However, the underlying neuronal and genetic mechanisms remain poorly understood. Here, we show in\n                    <jats:italic toggle=\"yes\">Drosophila<\/jats:italic>\n                    that the loss of the circadian clock gene\n                    <jats:italic toggle=\"yes\">period<\/jats:italic>\n                    exacerbates the ALAN-induced shift towards nocturnal behaviour, with a more pronounced effect on males. In contrast, the loss of\n                    <jats:italic toggle=\"yes\">cycle<\/jats:italic>\n                    has no such effect on males or females;\n                    <jats:italic toggle=\"yes\">cyc<\/jats:italic>\n                    null mutants are nocturnal under standard light\u2012dark cycles, and their activity and sleep profiles are minimally or not affected by ALAN exposure. CRISPR-Cas9 knockout of\n                    <jats:italic toggle=\"yes\">period<\/jats:italic>\n                    in most clock neurons resembles the null mutant phenotype. Our results show that mutations in components of the positive and negative limbs of the circadian clock result in distinct responses to nocturnal light and highlight the role of genetic factors in modulating behavioural plasticity in response to environmental perturbations.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2025.1170","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T23:06:36Z","timestamp":1756249596000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sexually dimorphic and clock gene-specific effects of artificial light at night on\n                    <i>Drosophila<\/i>\n                    behavioural rhythms"],"prefix":"10.1098","volume":"292","author":[{"given":"Ausra","family":"Pranevicius","sequence":"first","affiliation":[{"name":"Neuroscience and Behavior, Barnard College","place":["New York, 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