{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:35:16Z","timestamp":1772156116976,"version":"3.50.1"},"reference-count":73,"publisher":"The Royal Society","issue":"2054","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Science, Lund University"},{"DOI":"10.13039\/100001388","name":"Wenner-Gren Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001388","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Danish Rod and Net Licence Funds"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Proc. R. Soc. B."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    Pharmaceutical contaminants reaching natural aquatic ecosystems can affect fish behaviour, modifying activity patterns, foraging behaviour and antipredator responses. While laboratory-based studies can offer key insights, assessing the ecological relevance of these findings requires field-based approaches. Therefore, we examined the effects of oxazepam, a widely prescribed anxiolytic drug, on the behaviour of a cyprinid fish (the common roach,\n                    <jats:italic toggle=\"yes\">Rutilus rutilus<\/jats:italic>\n                    ) in the wild, combining slow-release exposure implants with continuous tracking via acoustic telemetry. To add ecological realism, we created a landscape of fear with an uneven distribution of resources (macrophytes) and exposure to predators (pike,\n                    <jats:italic toggle=\"yes\">Esox lucius<\/jats:italic>\n                    ), additionally testing the effects of the drug on roach habitat selection and predator\u2013prey interactions. Fish exposed to the drug showed an increased swimming activity and speed, but exhibited a more constrained spatial distribution in the pond, favouring areas with higher refuge availability. Both exposed and unexposed fish modified their habitat use in the presence of predators. Exposed fish appeared to get closer to the predators when these were caged, but not when predators were free-roaming. Our findings highlight the importance of considering ecological context to understand how pharmaceuticals affect fish behaviour, which is crucial for assessing risks at population and ecosystem levels.\n                  <\/jats:p>","DOI":"10.1098\/rspb.2025.1443","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T23:06:18Z","timestamp":1757459178000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impacts of an anxiolytic drug on fish behaviour and habitat use in a natural landscape"],"prefix":"10.1098","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-8983","authenticated-orcid":true,"given":"Natalia","family":"Sandoval Herrera","sequence":"first","affiliation":[{"name":"Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences","place":["901 83 Ume\u00e5, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin S.","family":"McCallum","sequence":"additional","affiliation":[{"name":"Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences","place":["901 83 Ume\u00e5, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Baktoft","sequence":"additional","affiliation":[{"name":"National Institute of Aquatic Resources, Danish Technical University","place":["8600 Silkeborg, Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Br\u00f6nmark","sequence":"additional","affiliation":[{"name":"Aquatic Ecology Unit, Department of Biology, Lund University, Lund 223 62, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cerveny","sequence":"additional","affiliation":[{"name":"Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences","place":["901 83 Ume\u00e5, Sweden"]},{"name":"Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice","place":["389 25 Vodnany, Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-1317","authenticated-orcid":true,"given":"Lars-Anders","family":"Hansson","sequence":"additional","affiliation":[{"name":"Aquatic Ecology Unit, Department of Biology, Lund University, Lund 223 62, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences","place":["901 83 Ume\u00e5, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Hulth\u00e9n","sequence":"additional","affiliation":[{"name":"Aquatic Ecology Unit, Department of Biology, Lund University, Lund 223 62, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-9835","authenticated-orcid":true,"given":"P. Anders","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Aquatic Ecology Unit, Department of Biology, Lund University, Lund 223 62, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Brodin","sequence":"additional","affiliation":[{"name":"Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences","place":["901 83 Ume\u00e5, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2009.09.021"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114150"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00299"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.1297"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0580"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113947119"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134780"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2019.0615"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226850"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.130169"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eap.2454"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2022.05.009"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/faf.12125"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.15473"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/aru183"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2016.11.008"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4290"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12844"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255642"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40462-023-00419-9"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2015.11.005"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.14191"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126534"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b01975"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsenvironau.4c00056"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/02772248.2018.1485925"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105672"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.05.488"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.11.228"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3772"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2019.01.004"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2022.06.007"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1139\/z01-094"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1461-0248.2004.00661.x"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg1780"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/es8005173"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msl188"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.02.126"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40317-020-00211-1"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2656.13610"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.13446"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.13597"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2010.02545.x"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002270000517"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12559"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.13815"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.14025"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.13745"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-statistics-042720-124436"},{"key":"e_1_3_7_51_2","unstructured":"Oksanen J et al. 2020 Vegan: community ecology package. R Package."},{"key":"e_1_3_7_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9671.2012.01353.x"},{"key":"e_1_3_7_53_2","first-page":"137","article-title":"Size-dependent diet composition and feeding of Eurasian perch (Perca fluviatilis) and northern pike (Esox lucius) in the Baltic Sea","volume":"24","author":"Jacobson P","year":"2019","unstructured":"Jacobson P, Bergstrom U, Eklof J. 2019 Size-dependent diet composition and feeding of Eurasian perch (Perca fluviatilis) and northern pike (Esox lucius) in the Baltic Sea. Boreal Env. Res. 24, 137\u2013153.","journal-title":"Boreal Env. Res."},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781315119076"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176714"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00442-010-1564-x"},{"key":"e_1_3_7_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172217"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001957"},{"key":"e_1_3_7_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2016.00081"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2017.1352214"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/jai.13980"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.13.1177.38089"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.04.002"},{"key":"e_1_3_7_64_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408440802026281"},{"key":"e_1_3_7_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103232"},{"key":"e_1_3_7_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22069"},{"key":"e_1_3_7_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0170-4"},{"key":"e_1_3_7_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-2501-5"},{"key":"e_1_3_7_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00877183"},{"key":"e_1_3_7_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.09.070"},{"key":"e_1_3_7_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c05587"},{"key":"e_1_3_7_72_2","doi-asserted-by":"publisher","DOI":"10.1086\/675504"},{"key":"e_1_3_7_73_2","unstructured":"Sandoval HN et al. 2025 Data from: Impacts of an anxiolytic drug on fish behaviour and habitat use in a natural landscape. Dryad Digital Repository. (doi:10.5061\/dryad.c2fqz61mh)"},{"key":"e_1_3_7_74_2","unstructured":"Sandoval Herrera N McCallum ES Baktoft H Br\u0151nmark C Cerveny D Hansson LA et al. 2025 Supplementary material from: Impacts of an anxiolytic drug on fish behaviour and habitat use in a natural landscape. Figshare (doi:10.6084\/m9.figshare.c.8010489)"}],"container-title":["Proceedings of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2025.1443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rspb.2025.1443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.2025.1443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T15:22:32Z","timestamp":1757604152000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rspb.2025.1443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":73,"journal-issue":{"issue":"2054","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1098\/rspb.2025.1443"],"URL":"https:\/\/doi.org\/10.1098\/rspb.2025.1443","relation":{"has-review":[{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSPB.2025.1443\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1471-2954"],"issn-type":[{"value":"1471-2954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20251443"}}