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Within Europe, this has its focus in the virtual physiological human (VPH), which is an evolving entity that has emerged from the EuroPhysiome initiative and the strategy for the EuroPhysiome (STEP) consortium. The VPH is intended to be a solution to common infrastructure needs for physiome projects across the globe, providing a unifying architecture that facilitates integration and prediction, ultimately creating a framework capable of describing\n            <jats:italic>Homo sapiens in silico<\/jats:italic>\n            . The routine reliance of the biomedical industry, biomedical research and clinical practice on information technology (IT) highlights the importance of a tailor-made and robust IT infrastructure, but numerous challenges need to be addressed if the VPH is to become a mature technological reality. Appropriate investment will reap considerable rewards, since it is anticipated that the VPH will influence all sectors of society, with implications predominantly for improved healthcare, improved competitiveness in industry and greater understanding of (patho)physiological processes. This paper considers issues pertinent to the development of the VPH, highlighted by the work of the STEP consortium.\n          <\/jats:p>","DOI":"10.1098\/rsta.2008.0089","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T13:22:29Z","timestamp":1213881749000},"page":"2979-2999","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":80,"title":["The EuroPhysiome, STEP and a roadmap for the virtual physiological human"],"prefix":"10.1098","volume":"366","author":[{"given":"J.W","family":"Fenner","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering, University of Sheffield, I Floor, Royal Hallamshire HospitalGlossop Road, Sheffield S10 2JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Brook","sequence":"additional","affiliation":[{"name":"Division of Applied Mathematics, University of NottinghamUniversity Park, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Clapworthy","sequence":"additional","affiliation":[{"name":"Institute for Research in Applicable Computing, University of BedfordshireBedfordshire LU1 3JU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.V","family":"Coveney","sequence":"additional","affiliation":[{"name":"Centre for Computational Science, University College London20 Gordon Street, London WC1H 0AJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Feipel","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Biomechanics and Organogenesis (LABO), Universit\u00e9 Libre de BruxellesLennik Street 808, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation CenterS\u00f8ndre Skovvej 15, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R","family":"Hose","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering, University of Sheffield, I Floor, Royal Hallamshire HospitalGlossop Road, Sheffield S10 2JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Kohl","sequence":"additional","affiliation":[{"name":"Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, University of OxfordSherrington Building, Parks Road, Oxford OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lawford","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering, University of Sheffield, I Floor, Royal Hallamshire HospitalGlossop Road, Sheffield S10 2JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M","family":"McCormack","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering, University of Sheffield, I Floor, Royal Hallamshire HospitalGlossop Road, Sheffield S10 2JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Pinney","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Clinical Engineering, University of Sheffield, I Floor, Royal Hallamshire HospitalGlossop Road, Sheffield S10 2JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R","family":"Thomas","sequence":"additional","affiliation":[{"name":"Informatiques, Biologie Int\u00e9grative et Syst\u00e8mes Complexes, IBISC FRE 2873 CNRSTour Evry 2, 4\u00e8me \u00e9tage, 91000 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Van Sint Jan","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Biomechanics and Organogenesis (LABO), Universit\u00e9 Libre de BruxellesLennik Street 808, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Waters","sequence":"additional","affiliation":[{"name":"Mathematical Institute, University of Oxford24\u201329 St Giles', Oxford OX1 3LB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Viceconti","sequence":"additional","affiliation":[{"name":"Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzolivia di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2008,6,17]]},"reference":[{"key":"e_1_3_2_2_1","unstructured":"Arlington S. 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