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Decomposition of intramuscular signals into individual motor unit action potentials consists in detection and classification, usually followed by separation of superimposed action potentials. Although intramuscular EMG signal decomposition is the primary tool for physiological investigations of motor unit properties, it is rarely applied in clinical routine, because of the need for human interaction and the difficulty in interpreting the quantitative data provided by EMG signal decomposition to support clinical decisions. The current clinical use of intramuscular EMG signals relates to the diagnosis of myopathies, of diseases of the \u03b1-motor neuron and of the neuromuscular junction through the analysis of the interference signal or of the shape of some motor unit action potentials, usually without a full decomposition of the signal.<\/jats:p>","DOI":"10.1098\/rsta.2008.0235","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T22:54:25Z","timestamp":1226616865000},"page":"357-368","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":122,"title":["Analysis of intramuscular electromyogram signals"],"prefix":"10.1098","volume":"367","author":[{"given":"Roberto","family":"Merletti","sequence":"first","affiliation":[{"name":"Laboratorio di Ingegneria del Sistema Neuromuscolare (LISIN), Dipartimento di ElettronicaPolitecnico di Torino, 10129 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Farina","sequence":"additional","affiliation":[{"name":"Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2008,11,11]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1929.sp002557"},{"key":"e_1_3_2_3_1","unstructured":"Basmajian J.V& De Luca C.J Muscles alive: their functions revealed by electromyography. 5th edn. 1985 Baltimore MD:William and Wilkins."},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.01.016"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1957.tb01411.x"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.1972.324140"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014294"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-468X(73)90006-8"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.12.002"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.900250"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-6411(00)00051-1"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(01)00510-6"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00788.2007"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00310-2"},{"key":"e_1_3_2_15_1","first-page":"1","article-title":"Electrical activity and force during voluntary contraction of normal and diseased muscle","volume":"63","author":"Fuglsang-Frederiksen A","year":"1981","journal-title":"Acta Neurol. 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