{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:55:58Z","timestamp":1793030158064,"version":"4.5.0"},"reference-count":10,"publisher":"The Royal Society","issue":"1920","license":[{"start":{"date-parts":[[2010,6,13]],"date-time":"2010-06-13T00:00:00Z","timestamp":1276387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. A."],"published-print":{"date-parts":[[2010,6,13]]},"abstract":"<jats:p>European funding under framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for nearly 2 years. The VPH network of excellence (NoE) is helping in the development of common standards, open-source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also helping to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by framework 6 strategy for a European physiome (STEP) project in 2006. It is now time to assess the accomplishments of the last 2 years and update the STEP vision for the VPH. We consider the biomedical science, healthcare and information and communications technology challenges facing the project and we propose the VPH Institute as a means of sustaining the vision of VPH beyond the time frame of the NoE.<\/jats:p>","DOI":"10.1098\/rsta.2010.0048","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T03:28:19Z","timestamp":1272857299000},"page":"2595-2614","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":118,"title":["A vision and strategy for the virtual physiological human in 2010 and beyond"],"prefix":"10.1098","volume":"368","author":[{"given":"Peter","family":"Hunter","sequence":"first","affiliation":[{"name":"Auckland Bioengineering Institute (ABI\u2009), University of Auckland, Auckland, New Zealand"},{"name":"Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Coveney","sequence":"additional","affiliation":[{"name":"Centre for Computational Science, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"de Bono","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fenner","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Science (Medical Physics Group\u2009), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro F.","family":"Frangi","sequence":"additional","affiliation":[{"name":"Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB\u2009), Universitat Pompeu Fabra, Barcelona, Spain"},{"name":"Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN\u2009), Barcelona, Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA\u2009), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Hose","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Science (Medical Physics Group\u2009), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kohl","sequence":"additional","affiliation":[{"name":"Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Lawford","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Science (Medical Physics Group\u2009), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"McCormack","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Science (Medical Physics Group\u2009), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Mendes","sequence":"additional","affiliation":[{"name":"Centre for Computational Science, University College London, London, 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Tegner","sequence":"additional","affiliation":[{"name":"Department Medicine, Unit for Computational Medicine, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Randall Thomas","sequence":"additional","affiliation":[{"name":"EA IBISC University of Evry-Val d\u2019Essonne, Evry, France"},{"name":"CNRS, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Tollis","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Laboratory (BMI\u2009), Institute of Computer Science (ICS\u2009), Foundation for Research and Technology (FORTH\u2009) and Computer Science Department, University of Crete, 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