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Cardiac function can be profoundly altered by the reflex activation of cardiac autonomic nerves in response to inputs from baro-, chemo-, nasopharyngeal and other receptors as well as by central autonomic commands, including those associated with stress, physical activity, arousal and sleep. In the clinical setting, slowly progressive autonomic failure frequently results from neurodegenerative disorders, whereas autonomic hyperactivity may result from vascular, inflammatory or traumatic lesions of the autonomic nervous system, adverse effects of drugs and chronic neurological disorders. Both acute and chronic manifestations of an imbalanced brain\u2013heart interaction have a negative impact on health. Simple, widely available and reliable cardiovascular markers of the sympathetic tone and of the sympathetic\u2013parasympathetic balance are lacking. A deeper understanding of the connections between autonomic cardiac control and brain dynamics through advanced signal and neuroimage processing may lead to invaluable tools for the early detection and treatment of pathological changes in the brain\u2013heart interaction.<\/jats:p>","DOI":"10.1098\/rsta.2015.0181","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:58:05Z","timestamp":1459817885000},"page":"20150181","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":237,"title":["Brain\u2013heart interactions: physiology and clinical implications"],"prefix":"10.1098","volume":"374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-3892","authenticated-orcid":false,"given":"Alessandro","family":"Silvani","sequence":"first","affiliation":[{"name":"PRISM Lab, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Calandra-Buonaura","sequence":"additional","affiliation":[{"name":"Autonomic Unit, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"},{"name":"IRCCS, Institute of Neurological Sciences of Bologna, Bellaria University Hospital, Block G, Via Altura 3, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A. 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