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For example, the gecko can adhere to rough, wet and dirty surfaces; however, most synthetic mimics cannot maintain function when faced with a similar situation. The solution to this problem lies in a more thorough investigation of the natural system. Here, we review the adhesive system of the gecko toe pad, as well as the far less-well-studied anti-adhesive system that results from the chemistry and structure of the toe pad (superhydrophobicity). This paradoxical relationship serves as motivation to study functional optimization at the system level. As an example, we experimentally investigate the role of surface lipids in adhesion and anti-adhesion, and find a clear performance trade-off related to shear adhesion in air on a hydrophilic surface. This represents the first direct investigation of the role of surface lipids in gecko adhesion and anti-adhesion, and supports the argument that a system-level approach is necessary to elucidate optimization in biological systems. Without such an approach, bioinspired designs will be limited in functionality and context, especially compared to the natural systems they mimic.<\/jats:p><jats:p>This article is part of the themed issue \u2018Bioinspired hierarchically structured surfaces for green science\u2019.<\/jats:p>","DOI":"10.1098\/rsta.2016.0184","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T12:14:57Z","timestamp":1467202497000},"page":"20160184","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Superhydrophobicity of the gecko toe pad: biological optimization versus laboratory maximization"],"prefix":"10.1098","volume":"374","author":[{"given":"Alyssa Y.","family":"Stark","sequence":"first","affiliation":[{"name":"Integrated Bioscience Program, , University of Akron, Akron, OH 44325, USA"},{"name":"Department of Biology, University of Louisville, Louisville, KY 40292, 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