{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:22:32Z","timestamp":1778624552419,"version":"3.51.4"},"reference-count":54,"publisher":"The Royal Society","issue":"2126","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"\u2018Ministerio de Econom\u00eda y Competitividad\u2019 and \u2018European Regional Development Fund\u2019","award":["TEC2014-53196-R and DPI2017-84280-R"],"award-info":[{"award-number":["TEC2014-53196-R and DPI2017-84280-R"]}]},{"name":"Cooperation Programme Interreg V-A Spain-Portugal POCTEP","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]},{"name":"Consejer\u00eda de Educaci\u00f3n de la Junta de Castilla y Le\u00f3n\u2019 and FEDER","award":["VA037U16"],"award-info":[{"award-number":["VA037U16"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. A."],"published-print":{"date-parts":[[2018,8,13]]},"abstract":"<jats:p>\n                    Normal pressure hydrocephalus (NPH) encompasses a heterogeneous group of disorders generally characterized by clinical symptoms, ventriculomegaly and anomalous cerebrospinal fluid (CSF) dynamics. Lumbar infusion tests (ITs) are frequently performed in the preoperatory evaluation of patients who show NPH features. The analysis of intracranial pressure (ICP) signals recorded during ITs could be useful to better understand the pathophysiology underlying NPH and to assist treatment decisions. In this study, 131 ICP signals recorded during ITs were analysed using two continuous wavelet transform (CWT)-derived parameters: Jensen divergence (JD) and spectral flux (SF). These parameters were studied in two frequency bands, associated with different components of the signal:\n                    <jats:italic>B<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    (0.15\u20130.3\u2009Hz), related to respiratory blood pressure oscillations; and\n                    <jats:italic>B<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    (0.67\u20132.5\u2009Hz), related to ICP pulse waves. Statistically significant differences (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20091.70\u2009\u00d7\u200910\n                    <jats:sup>\u22123<\/jats:sup>\n                    , Bonferroni-corrected Wilcoxon signed-rank tests) in pairwise comparisons between phases of ITs were found using the mean and standard deviation of JD and SF. These differences were mainly found in\n                    <jats:italic>B<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    , where a lower irregularity and variability, together with less prominent time-frequency fluctuations, were found in the hypertension phase of ITs. Our results suggest that wavelet analysis could be useful for understanding CSF dynamics in NPH.\n                  <\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018Redundancy rules: the continuous wavelet transform comes of age\u2019.<\/jats:p>","DOI":"10.1098\/rsta.2017.0251","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T03:35:11Z","timestamp":1531107311000},"page":"20170251","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Continuous wavelet transform in the study of the time-scale properties of intracranial pressure in hydrocephalus"],"prefix":"10.1098","volume":"376","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-0351","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Biomedical Engineering Group (GIB), Department T.S.C.I.T., E.T.S. 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