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A."],"published-print":{"date-parts":[[2022,7,25]]},"abstract":"<jats:p>In this research, a vagus nerve stimulator has been developed and miniaturized for use in epilepsy research. The board contains all the components necessary for its operation during the standard duration of the experiments, being possible to control it once implanted and even being able to reuse it. The VNS system has been designed for rodents since the VNS devices available for human are not only too large for laboratory animals, but also too expensive. With this solution the expenditure on materials made by laboratories is greatly reduced and bioethical considerations were kept in mind. The system was validated in hamsters.<\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018Advanced neurotechnologies: translating innovation for health and well-being\u2019.<\/jats:p>","DOI":"10.1098\/rsta.2021.0010","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T03:05:34Z","timestamp":1654484734000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["An affordable implantable vagus nerve stimulator system for use in animal research"],"prefix":"10.1098","volume":"380","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-5944","authenticated-orcid":true,"given":"\u00c1ngel","family":"Canal-Alonso","sequence":"first","affiliation":[{"name":"Bioinformatics, Intelligent Systems and Educational Technology (BISITE) Research Group, Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Casado-Vara","sequence":"additional","affiliation":[{"name":"Bioinformatics, Intelligent Systems and Educational Technology (BISITE) Research Group, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Castellano","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain"},{"name":"Institute of Neuroscience of Castilla y Le\u00f3n (INCYL), University of Salamanca, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Herrera-Santos","sequence":"additional","affiliation":[{"name":"Bioinformatics, Intelligent Systems and Educational Technology (BISITE) Research Group, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain"},{"name":"Institute of Neuroscience of Castilla y Le\u00f3n (INCYL), University of Salamanca, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"M\u00e0rquez-S\u00e0nchez","sequence":"additional","affiliation":[{"name":"Bioinformatics, Intelligent Systems and Educational Technology (BISITE) Research Group, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Mar\u00eda","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Institute of Neuroscience of Castilla y Le\u00f3n (INCYL), University of Salamanca, Salamanca, Spain"},{"name":"Department of Surgery, Faculty of Medicine, University of Salamanca, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Corchado","sequence":"additional","affiliation":[{"name":"Bioinformatics, Intelligent Systems and Educational Technology (BISITE) Research Group, Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32596-0"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.59"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14596"},{"key":"e_1_3_7_5_2","first-page":"4","article-title":"Epilepsy surgery","volume":"20","author":"Rugg-Gunn F","year":"2020","unstructured":"Rugg-Gunn F, Miserocchi A, McEvoy A. 2020 Epilepsy surgery. 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