{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:11:22Z","timestamp":1767161482754,"version":"3.48.0"},"reference-count":61,"publisher":"The Royal Society","issue":"856","license":[{"start":{"date-parts":[[1972,3,23]],"date-time":"1972-03-23T00:00:00Z","timestamp":70156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1972,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A study has been made of an iodine-deficient population living in an extended village in the Karakoram Himalayas. There is evidence that the incidence of goitre increases towards the lowest part of the village, in accordance with the findings of McCarrison, who worked in the same region in the early years of the twentieth century. McCarrison ascribed the variation of goitre incidence to increasing pollution of drinking water as it travelled downstream, and postulated a bacteriological goitrogenic factor. However, the observations reported here show no correlation between goitre incidence and the bacterial concentration of drinking water, nor are there iodine-metabolizing micro-organisms present in the water. It may be that a differential iodine deficiency throughout the village can account for the variation in goitre incidence, since the soil can adsorb appreciable amounts of radio-iodine. The indices of thyroid function show that all the inhabitants are exceptionally iodine-deficient, although most of them are clinically euthyroid. As well as having a greatly enhanced mean thyroid iodide clearance the population has a mean renal iodide clearance which is lower than normal. Intra-muscular injections of iodized oil were acceptable to the villagers, and 477 injections were administered. Fingerprints and palm prints were collected from a sample of the population, yielding a pattern distribution comparable with other populations in the Indian subcontinent. The ratio of PTC tasters to non-tasters among the inhabitants is not significantly different from the ratio found in Europe.<\/jats:p>","DOI":"10.1098\/rstb.1972.0007","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T17:23:53Z","timestamp":1166462633000},"page":"459-490","source":"Crossref","is-referenced-by-count":7,"title":["Endemic goitre in the Gilgit Agency, West Pakistan"],"prefix":"10.1098","volume":"263","author":[{"given":"J. A.","family":"Chapman","sequence":"first","affiliation":[{"name":"Biophysics Unit, Rheumatism Research Centre, University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. S.","family":"Grant","sequence":"additional","affiliation":[{"name":"The Schuster Laboratories, Department of Physics, University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Immunology Laboratory, Department of Bacteriology and Virology, University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalida","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Agency Hospital, Gilgit, West Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sardar","family":"Ul-Mulk","sequence":"additional","affiliation":[{"name":"Civil Hospital, Chitral, West Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Shahid","sequence":"additional","affiliation":[{"name":"Atomic Energy Medical Centre, Mayo Hospital, Lahore, West Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","unstructured":".8 53.5 44.9 14.3 - present study"},{"key":"p_2","unstructured":".4 52.8 45.8 14.4"},{"key":"p_3","unstructured":".2 60.4 38.4 13.7"},{"key":"p_4","doi-asserted-by":"crossref","unstructured":".8 50.9 41.2 13.3 Hughes (1967)","DOI":"10.1177\/026455056701300203"},{"key":"p_5","unstructured":".5 56.0 41.3 13.9 1|"},{"key":"p_6","doi-asserted-by":"crossref","unstructured":".9 54.7 41.4 13.8 f Srivastava (1965)","DOI":"10.1177\/0019466219650104"},{"key":"p_7","unstructured":"J1"},{"key":"p_8","doi-asserted-by":"crossref","unstructured":".1 59.0 38.9 13.7 Roberts et(1968)","DOI":"10.1007\/BF02043675"},{"key":"p_9","doi-asserted-by":"crossref","unstructured":".3 60.0 36.7 13.3 Renes (1948 a)","DOI":"10.1111\/j.1946-150X.1948.tb00816.x"},{"key":"p_10","doi-asserted-by":"crossref","unstructured":".3 55.2 42.5 14.0 Biswas (1936)","DOI":"10.4286\/ikakikaigakuzassi.14.1_42"},{"key":"p_11","doi-asserted-by":"crossref","unstructured":".4 53.6 39.2 13.2 Singh (1961)","DOI":"10.1111\/j.0033-0124.1961.136_39.x"},{"key":"p_12","unstructured":".4 59.3 33.3 12.6 Singh (1955)"},{"key":"p_13","doi-asserted-by":"crossref","unstructured":".1 57.4 39.4 13.6 Olivier (1911)","DOI":"10.2307\/30067200"},{"key":"p_14","doi-asserted-by":"crossref","unstructured":".2 53.1 45.8 14.5 Olivier (1961)","DOI":"10.1086\/renaissancenews.14.1.2857239"},{"key":"p_15","doi-asserted-by":"crossref","unstructured":".0 55.3 39.6 13.4 Gladkova (1957)","DOI":"10.5006\/0010-9312-13.9.39"},{"key":"p_16","unstructured":".5 52.2 45.4 13.3 Cummins & Shanklin"},{"key":"p_17","unstructured":"Barth F. 1965 Political leadership among Swat Pathans. London: The Athlone Press."},{"key":"p_18","first-page":"519","article-title":"Z","volume":"35","author":"Biswas P. C.","year":"1936","journal-title":"Morph. Anthrop."},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.18.1.120"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-26-11-1201"},{"key":"p_21","first-page":"1","article-title":"Anthropologie","volume":"67","author":"Chamla","year":"1963","journal-title":"Paris"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-23-12-1203"},{"key":"p_23","doi-asserted-by":"crossref","unstructured":"Cummins H. & Midlo C. 1943 Finger prints palms and soles. Philadelphia: Blakiston. (Reprinted 1961 New York: Dover).","DOI":"10.1097\/00000441-194402000-00018"},{"key":"p_24","first-page":"263","article-title":"Am. J. phys","volume":"22","author":"Cummins H.","year":"1937","journal-title":"Anthrop."},{"key":"p_25","first-page":"19","article-title":"Am. J. phys","volume":"20","author":"Cummins H.","year":"1935","journal-title":"Anthrop."},{"key":"p_26","first-page":"155","article-title":"Proc. natn","volume":"18","author":"Fox A. L.","year":"1932","journal-title":"Acad. Sci. U.S.A."},{"key":"p_27","first-page":"181","article-title":"Z","volume":"51","author":"Geipel G.","year":"1961","journal-title":"Morph. Anthrop."},{"key":"p_28","doi-asserted-by":"crossref","unstructured":"Gladkova T. D. 1957 SovietAntropl. 1 83.","DOI":"10.5694\/j.1326-5377.1957.tb49485.x"},{"key":"p_29","doi-asserted-by":"crossref","unstructured":"Hamid A. & Warkentin B. P. 1967 Soil Sci. 104 279.","DOI":"10.1097\/00010694-196710000-00008"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1949.tb02419.x"},{"key":"p_31","doi-asserted-by":"crossref","unstructured":"Harris H. Kalmus H. & Trotter W. R. 1949 Lancet II 1038.","DOI":"10.1016\/S0140-6736(49)91605-0"},{"key":"p_32","doi-asserted-by":"crossref","unstructured":"Holt S. B. 1968 The genetics o f dermal ridges. Springfield 111.: Chas. Thomas.","DOI":"10.1001\/archinte.1969.00300110113042"},{"key":"p_33","doi-asserted-by":"crossref","unstructured":"Hughes D. R. 1967 Man 2 119.","DOI":"10.2307\/2798659"},{"key":"p_34","unstructured":"Ibbertson H. K. Pearl M. & Tait J. M. 1969 I.A.E.A. Report on the Himalayan Goitre Research Project."},{"key":"p_35","first-page":"14","article-title":"Biology hum","volume":"22","author":"Kalmus H.","year":"1956","journal-title":"Affairs"},{"key":"p_36","unstructured":"Katalymov M. V. & Churbanov V. M. i960 Dokl. Akad. Nauk. SSSR 131 1191."},{"key":"p_37","doi-asserted-by":"crossref","unstructured":"Kitchin F. D. Howel-Evans W. Clarke C. A. McConnell R. B. & Shepphard P. M. 1959 Br. med. J. i 1069.","DOI":"10.1136\/bmj.1.5129.1069"},{"key":"p_38","article-title":"Med.-chr","volume":"89","author":"McGarrison R.","year":"1906","journal-title":"Trans."},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1909.0003"},{"key":"p_40","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1911.0016"},{"key":"p_41","unstructured":"McCarrison R. 1913 The etiology o f endemic goitre ( Danielsson. theMilroy Lectures for 1913). London: Bale Sons and"},{"key":"p_42","first-page":"207","article-title":"Indian J . med","volume":"15","author":"McCarrison R.","year":"1927","journal-title":"Res."},{"key":"p_43","unstructured":"Matovinovic J. i960 WHO Report."},{"key":"p_44","first-page":"405","volume":"9","author":"Myant N. B.","year":"1950","journal-title":"Clin. Sci."},{"key":"p_45","unstructured":"Olivier G. 1961 Anthropologie des Tamouls du Sud de I'lnde. Paris: Ecole Francaise d'Extreme-Orient."},{"key":"p_46","first-page":"217","article-title":"Bull","volume":"18","author":"Perez C.","year":"1958","journal-title":"Wld Hlth Org."},{"key":"p_47","doi-asserted-by":"crossref","unstructured":"Raja M. E. & Babcock L. K. 1961 Soil Sci. 91 1.","DOI":"10.1097\/00010694-196101000-00001"},{"key":"p_48","first-page":"277","article-title":"a Acta neerl","volume":"6","author":"Renes R. C.","year":"1948","journal-title":"Morph."},{"key":"p_49","first-page":"271","article-title":"6 Acta neerl","volume":"6","author":"Renes R. C.","year":"1948","journal-title":"Morph."},{"key":"p_50","doi-asserted-by":"crossref","unstructured":"Roberts D. F. Coope E. M. Jackson F. S. Turner R. W. D. & Ward M. P. 1968 Man 3 5.","DOI":"10.2307\/2799408"},{"key":"p_51","doi-asserted-by":"crossref","unstructured":"Simpson B. W. 1930 N .Z. J l Agric. 41 179.","DOI":"10.1177\/001452463004100705"},{"key":"p_52","doi-asserted-by":"crossref","unstructured":"Singh I. P. 1955 Anthropologist 2 36.","DOI":"10.1080\/2052546.1955.11908181"},{"key":"p_53","first-page":"169","article-title":"East","volume":"14","author":"Singh I. P.","year":"1961","journal-title":"Anthrop."},{"key":"p_54","first-page":"436","article-title":"Ohio J","volume":"32","author":"Snyder L. H.","year":"1932","journal-title":"Sci."},{"key":"p_55","first-page":"99","article-title":"Am. J. phys","volume":"23","author":"Srivastava R. P.","year":"1965","journal-title":"Anthrop."},{"key":"p_56","unstructured":"Umaly R. C. 1967 Ph.D. Thesis: Birmingham."},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-2-175"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-4-551"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-27-7-913"},{"key":"p_60","unstructured":"Wayne E. J. Koutras D. A. & Alexander W. D. 1964 Clinical aspects o f iodine metabolism. Oxford: Blackwell."},{"key":"p_61","unstructured":"Weiner J. S. & Lourie J. A. 1969 Human biology - A guide tofield methods ( Handbook No. 9 ). Oxford: Blackwell."}],"container-title":["Philosophical Transactions of the Royal Society of London. B, Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1972.0007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/263\/856\/459\/335335\/rstb.1972.0007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/263\/856\/459\/335335\/rstb.1972.0007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:07:01Z","timestamp":1767161221000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/263\/856\/459\/54134\/Endemic-goitre-in-the-Gilgit-Agency-West-Pakistan"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3,23]]},"references-count":61,"journal-issue":{"issue":"856","published-print":{"date-parts":[[1972,3,23]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.1972.0007","relation":{},"ISSN":["0080-4622","2054-0280"],"issn-type":[{"type":"print","value":"0080-4622"},{"type":"electronic","value":"2054-0280"}],"subject":[],"published":{"date-parts":[[1972,3,23]]}}}