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The data indicate that the most likely molecular basis for these common abnormal haemoglobins is a single base substitution in the \u03b1-chain termination codon. Because these variants are produced inefficiently they give rise to the clinical picture of \u03b1-thalassaemia. When these findings are taken together with recent work regarding the molecular basis for other forms of a-thalassaemia it is possible to build up a fairly complete picture of the molecular pathology of the \u03b1-thalassaemias.<\/jats:p>","DOI":"10.1098\/rstb.1975.0061","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T16:31:17Z","timestamp":1166200277000},"page":"411-455","source":"Crossref","is-referenced-by-count":43,"title":["The \u03b1-chain-termination mutants and their relation to the \u03b1-thalassaemias"],"prefix":"10.1098","volume":"271","author":[{"given":"David John","family":"Weatherall","sequence":"first","affiliation":[{"name":"Department of Haematology, University of Liverpool"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Brian","family":"Clegg","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Liverpool"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","first-page":"194","article-title":"H om ozygous H b J T o n g arik i: evidence for only one a Ip h a ch ain stru ctu ra l locus in M elanesians","volume":"169","author":"Shreffler D. 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