{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:54:08Z","timestamp":1787820848710,"version":"build-2784847793"},"reference-count":6,"publisher":"The Royal Society","issue":"1071","license":[{"start":{"date-parts":[[1981,8,14]],"date-time":"1981-08-14T00:00:00Z","timestamp":366595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Both iron and copper play critical biochemical roles in the post-translational modifications of collagen and elastin. These modifications are essential to the maturation and structural integrity of these proteins. Iron functions in the hydroxylation of specific prolyl and lysyl residues in collagen, a process that must occur before the triple helix can form and be extruded from the cell. Copper functions in the oxidative deamination of specific lysyl residues in the soluble forms of both elastin and collagen. This process is essential for crosslink formation and the structural integrity of these proteins. While there is no evidence that nutritional iron deficiency results in connective tissue pathology, copper deficiency impairs crosslink formation and results in gross pathology of bones, lungs and the cardiovascular system of many animal species.<\/jats:p>","DOI":"10.1098\/rstb.1981.0091","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T13:37:25Z","timestamp":1166189845000},"page":"91-104","source":"Crossref","is-referenced-by-count":41,"title":["Roles for iron and copper in connective tissue biosynthesis"],"prefix":"10.1098","volume":"294","author":[{"given":"B. L.","family":"O'Dell","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, U. S. A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"p_1","unstructured":"chick cartilage 60000 Siegel & Fu (1976)"},{"key":"p_2","unstructured":"chick cartilage 28000 Stassen (1976)"},{"key":"p_3","unstructured":"chick aorta 60000 H arris etal. (1974)"},{"key":"p_4","unstructured":"bovine aorta 60000 V idal etal. (1975)"},{"key":"p_5","unstructured":"bovine aorta 30000 Jo rd a n et al. (1976)"},{"key":"p_6","unstructured":"bovine ligam ent 30000 K agan etal. (1979)"}],"container-title":["Philosophical Transactions of the Royal Society of London. B, Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1981.0091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/294\/1071\/91\/332560\/rstb.1981.0091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/294\/1071\/91\/332560\/rstb.1981.0091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:44:41Z","timestamp":1767163481000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/294\/1071\/91\/53431\/Roles-for-iron-and-copper-in-connective-tissue"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8,14]]},"references-count":6,"journal-issue":{"issue":"1071","published-print":{"date-parts":[[1981,8,14]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.1981.0091","relation":{},"ISSN":["0080-4622","2054-0280"],"issn-type":[{"value":"0080-4622","type":"print"},{"value":"2054-0280","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8,14]]}}}