{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:47:33Z","timestamp":1767163653269,"version":"3.48.0"},"reference-count":0,"publisher":"The Royal Society","issue":"1071","license":[{"start":{"date-parts":[[1981,8,14]],"date-time":"1981-08-14T00:00:00Z","timestamp":366595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aspects of the pathology of copper deficiency in several species, and cobalt deficiency in sheep, are summarized. An attempt is made to interpret morphological changes in copper-deficient animals in terms of biochemical defects. The common denominator may be mitochondrial lesions, with a generalized effect on energy-dependent synthetic functions of the cell. In copper deficiency, such defects can be attributed to depletion of copper-dependent enzymes, while deficiency of cobalt in ruminants is, in effect, deficiency of vitamin B12. The pathological consequences of vitamin B12 deficiency form a syndrome, notable features of which are neurological and muscular lesions, in which the metabolic consequences of hepatic damage may play a significant role.<\/jats:p>","DOI":"10.1098\/rstb.1981.0096","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T13:37:25Z","timestamp":1166189845000},"page":"153-169","source":"Crossref","is-referenced-by-count":24,"title":["Pathological consequences of copper deficiency and cobalt deficiency"],"prefix":"10.1098","volume":"294","author":[{"given":"B. F.","family":"Fell","sequence":"first","affiliation":[{"name":"Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","container-title":["Philosophical Transactions of the Royal Society of London. B, Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1981.0096","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/294\/1071\/153\/332504\/rstb.1981.0096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/294\/1071\/153\/332504\/rstb.1981.0096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:43:46Z","timestamp":1767163426000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/294\/1071\/153\/53408\/Pathological-consequences-of-copper-deficiency-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8,14]]},"references-count":0,"journal-issue":{"issue":"1071","published-print":{"date-parts":[[1981,8,14]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.1981.0096","relation":{},"ISSN":["0080-4622","2054-0280"],"issn-type":[{"type":"print","value":"0080-4622"},{"type":"electronic","value":"2054-0280"}],"subject":[],"published":{"date-parts":[[1981,8,14]]}}}