{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:04:18Z","timestamp":1771013058435,"version":"3.50.1"},"reference-count":1,"publisher":"The Royal Society","issue":"1072","license":[{"start":{"date-parts":[[1981,8,18]],"date-time":"1981-08-18T00:00:00Z","timestamp":366940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Von Willebrand pigs have all the manifestations of the severe human disease. The role of Willebrand antigen (VIII R:AG) and ristocetin cofactor (VIII: RWF) was assessed in these pigs by (1) transfusion and (2) \u2019in vitro' bleeding time assay. The skin bleeding time became normal when the level of transfused Willebrand factor (VIII R: AG\/RWF) was raised in the plasma above 30 U\/dl. After single or repeated transfusions, skin capillary endothelium and platelets were still distinguished from normal by VIII R:AG deficiency. When incisions in excised porcine skin (\u2019in vitro' bleeding time) were perfused with blood and plasma fractions, haemostasis occurred when plasmatic Willebrand factor exceeded 30 U\/dl whether the skin or platelets came from normal or from von Willebrand pigs. The platelet plug occluding the skin incision contained VIII R:AG by immunofluorescence. Willebrand factor appears to coat surfaces and to serve as a platelet attachment protein. These bleeder pigs are resistant to atherosclerosis. If platelets are involved in early atheroscolerotic lesions, the role of Willebrand factor in platelet - blood vessel interaction may be important.<\/jats:p>","DOI":"10.1098\/rstb.1981.0105","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T17:21:37Z","timestamp":1166462497000},"page":"267-279","source":"Crossref","is-referenced-by-count":6,"title":["The role of Willebrand factor in platelet \u2014 blood vessel interaction, including a discussion of resistance to atherosclerosis in pigs with von Willebrand\u2019s disease"],"prefix":"10.1098","volume":"294","author":[{"given":"E. J. W.","family":"Bowie","sequence":"first","affiliation":[{"name":"Hematology Research, Mayo Clinic and Mayo Foundation, Rochester, Minesota 55901, U. S. A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Fuster","sequence":"additional","affiliation":[{"name":"Hematology Research, Mayo Clinic and Mayo Foundation, Rochester, Minesota 55901, U. S. A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. N.","family":"Fass","sequence":"additional","affiliation":[{"name":"Hematology Research, Mayo Clinic and Mayo Foundation, Rochester, Minesota 55901, U. S. A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Owen, Jr","sequence":"additional","affiliation":[{"name":"Hematology Research, Mayo Clinic and Mayo Foundation, Rochester, Minesota 55901, U. S. A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","first-page":"478","article-title":"Lab","volume":"29","author":"Moore S.","year":"1973","journal-title":"Invest."}],"container-title":["Philosophical Transactions of the Royal Society of London. B, Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1981.0105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/294\/1072\/267\/332596\/rstb.1981.0105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/294\/1072\/267\/332596\/rstb.1981.0105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:46:42Z","timestamp":1767163602000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/294\/1072\/267\/53442\/The-role-of-Willebrand-factor-in-platelet-blood"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8,18]]},"references-count":1,"journal-issue":{"issue":"1072","published-print":{"date-parts":[[1981,8,18]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.1981.0105","relation":{},"ISSN":["0080-4622","2054-0280"],"issn-type":[{"value":"0080-4622","type":"print"},{"value":"2054-0280","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8,18]]}}}