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The structure of horse spleen apoferritin, which has recently been refined, consists of 24 symmetrically related subunits forming a near-spherical hollow shell. In ferritin the central cavity is occupied by an iron core of \u2018ferrihydrite\u2019, a geologically ephem eral mineral found in hot or cold springs and in mine workings, or produced in the laboratory by heating solutions of ferric salts. Ferritin itself forms most readily from apoferritin, in the presence of dioxygen, from FeII, not FeIII . Access to its interior is through small intersubunit channels, and the protein influences both the rate of FeII-oxidation and the form of oxide produced.<\/jats:p>","DOI":"10.1098\/rstb.1984.0046","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T17:33:09Z","timestamp":1166463189000},"page":"551-565","source":"Crossref","is-referenced-by-count":446,"title":["Ferritin: design and formation of an iron-storage molecule"],"prefix":"10.1098","volume":"304","author":[{"given":"G. C.","family":"Ford","sequence":"first","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline May","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M. A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Treffry","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yariv","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, The University, Sheffield S10 2TN, U. 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