{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:13:06Z","timestamp":1767165186321,"version":"3.48.0"},"reference-count":7,"publisher":"The Royal Society","issue":"1132","license":[{"start":{"date-parts":[[1984,12,4]],"date-time":"1984-12-04T00:00:00Z","timestamp":470966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The genetic and acquired disorders of hum an haemoglobin provide a diverse group of naturally occurring models for analysing the regulation of protein synthesis. They include structural haemoglobin variants, thalassaemias, which are conditions in which there is a reduced rate ofglobin chain production, and hereditary persistence of foetal haemoglobin (HPFH ) in which there is an inherited abnormality in the switch from foetal to adult haemoglobin synthesis. The thalassaemias result from a diverse series of cis acting lesions of the globin genes which include deletions, insertions, frame shift mutations, and point mutations involving transcription, messenger RNA processing, initiation, termination, poly A addition and globin chain stability. Many forms of HPFH are due to deletions of the \u03b2-like gene cluster; it has been suggested that they may involve regions of the cluster which are involved in the regulation of the foetal to adult globin chain switch. So far, however, no regions of this type have been identified with certainty. The varieties of HPFH not associated with major gene deletions, or those caused by genetic determ inants that are not linked to the globin gene clusters, and some of the acquired forms of \u03b1 thalassaemia associated with mental retardation or leukaemia, may be more useful models for studying the regulation of the globin genes, particularly their developm ental control.<\/jats:p>","DOI":"10.1098\/rstb.1984.0125","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T17:33:09Z","timestamp":1166463189000},"page":"247-259","source":"Crossref","is-referenced-by-count":4,"title":["Genetic disorders of human haemoglobin as models for analysing gene regulation"],"prefix":"10.1098","volume":"307","author":[{"given":"David John","family":"Weatherall","sequence":"first","affiliation":[{"name":"M. R. C. Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Higgs","sequence":"additional","affiliation":[{"name":"M. R. C. Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. G.","family":"Wood","sequence":"additional","affiliation":[{"name":"M. R. C. Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Brian","family":"Clegg","sequence":"additional","affiliation":[{"name":"M. R. C. Molecular Haematology Unit, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Collins F. S. & Weissman S. M. 1984 The molecular genetics of human hemoglobin. In Progress in nucleic acids research and molecular biology. (In the press.)","DOI":"10.1016\/S0079-6603(08)60382-7"},{"key":"p_2","unstructured":"Higgs D. R. & Weatherall D. J. 1983 Alpha thalassaemia. In Current topics in hematology (ed. S. Piomelli & S. Yachnin) pp. 37-97. New York: Alan R. Liss."},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.14.120180.001045"},{"key":"p_4","unstructured":"Orkin S. H. Antonarakis S. E. & Kazazian H. H. 1983 Polymorphism and molecular pathology of the human beta-globin gene. In Progress in hematology X III (ed. E. B. Brown) pp. 49-73. New York: Grune & Stratton."},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1038\/296627a0"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb03904.x"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1042\/bj2150001"}],"container-title":["Philosophical Transactions of the Royal Society of London. B, Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1984.0125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/307\/1132\/247\/331388\/rstb.1984.0125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/307\/1132\/247\/331388\/rstb.1984.0125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:09:47Z","timestamp":1767164987000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/307\/1132\/247\/53033\/Genetic-disorders-of-human-haemoglobin-as-models"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12,4]]},"references-count":7,"journal-issue":{"issue":"1132","published-print":{"date-parts":[[1984,12,4]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.1984.0125","relation":{},"ISSN":["0080-4622","2054-0280"],"issn-type":[{"type":"print","value":"0080-4622"},{"type":"electronic","value":"2054-0280"}],"subject":[],"published":{"date-parts":[[1984,12,4]]}}}