{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:36:05Z","timestamp":1790746565026,"version":"4.1.0"},"reference-count":31,"publisher":"The Royal Society","issue":"1136","license":[{"start":{"date-parts":[[1985,2,19]],"date-time":"1985-02-19T00:00:00Z","timestamp":477619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is evidence that the cerebral cortex is involved in the perception of pain but no specific area appears to be the \u2018pain centre\u2019. Limited knowledge exists on the cortical processing of the noxious input. The nociceptors are most likely to activate at least two different systems with different characteristics. One has a bilateral cortical projection, no apparent topographical pattern, low synaptic security and excites cells in large areas. This system may give rise to the widespread increase in blood flow and the widely distributed surface potentials recorded in man following a painful stimulus. Noxious stimuli also excite a system with contralateral topographical projection, high synaptic security and termination in lamina IV. This system produces EPSP-IPSP sequences in cells in a restricted cortical area. Pronounced inhibition of cells in lamina IV and more superficial layers is induced by activity in low threshold afferents. Thus, similarly as at the segmental spinal level, the nociceptive input to cortical cells is processed and integrated with the activity in other afferent systems.<\/jats:p>","DOI":"10.1098\/rstb.1985.0035","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T17:33:09Z","timestamp":1166463189000},"page":"347-355","source":"Crossref","is-referenced-by-count":5,"title":["Cortical nociceptive systems"],"prefix":"10.1098","volume":"308","author":[{"given":"S. A.","family":"Andersson","sequence":"first","affiliation":[{"name":"Department of Physiology, University of G\u00f6teborg, Medicinaregatan 11, Fack, S-400 33 G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Rydenhag","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of G\u00f6teborg, Medicinaregatan 11, Fack, S-400 33 G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"p_1","first-page":"74","article-title":"Projection of different spinal pathways to the second somatic sensory area in cat. Acta physiol, scand. 56","volume":"194","author":"Andersson S. A.","year":"1962","journal-title":"Suppl."},{"key":"p_2","unstructured":"Andersson S. A. Keller O. Roos A. & Rydenhag B. 1977 Cortical projection of tooth pulp afferents in the cat. In Pain in the trigeminal region (ed. D. J. Anderson & B. Matthews) pp. 355-364. Amsterdam: Elsevier\/North-Holland Biomedical Press."},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90754-3"},{"key":"p_4","unstructured":"Andersson S. A. & Norrsell U. 1973 Unit activation in the post-central gyrus of the monkey via ventral spinal pathways. Acta physiol scand 87 47A-48A."},{"key":"p_5","first-page":"363","article-title":"Somatosensory cortical involvement in responses to noxious stimulation in the cat","volume":"20","author":"Berkley K. 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Psychiat."},{"key":"p_21","first-page":"201","article-title":"Neural mechanisms subserving cutaneous sensibility, with special reference to the role of afferent inhibition in sensory perception and discrimination","volume":"105","author":"Mountcastle V. B.","year":"1959","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1944.7.5.269"},{"key":"p_23","doi-asserted-by":"crossref","unstructured":"Penfield W. & Jasper H. H. 1954 Epilepsy and the functional anatomy of the human brain pp. 869. Boston Mass.: Little Brown & Co.","DOI":"10.1097\/00007611-195407000-00024"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(82)90132-4"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90086-6"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90085-4"},{"key":"p_27","unstructured":"Sessle B. J. 1979 Is the tooth pulp a `pure' source of noxious input? 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