{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:05:15Z","timestamp":1767351915103,"version":"3.48.0"},"reference-count":57,"publisher":"The Royal Society","issue":"1194","license":[{"start":{"date-parts":[[1988,6,15]],"date-time":"1988-06-15T00:00:00Z","timestamp":582336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Down\u2019s syndrome is the most common autosomal aberration and single cause of mental retardation in man. There is a close relation between advanced maternal age and Down\u2019s syndrome. The limitation of family size has made a considerable impact on the incidence of Down\u2019s syndrome. In Denmark in the 1950s, 50% of Down\u2019s syndrome cases were born to mothers over the age of 35. The percentage went down to 25% in the 1970s and was reduced by prenatal diagnosis to 8 % in the 1980s. For the period 1980-85 we followed the birth prevalence closely for the different maternal age groups. The birth prevalence was lowered for the age group over 35, but there was a steady rise for the age groups below 35. Early diagnosis, high rate of survival of light-for-date babies and babies with congenital heart defect, and, possibly, exogenous factors working on gametogenesis might be an explanation. To achieve a reduction in incidence, maternal x-fetoprotein (AFP)-serum screening for low values may be a possibility. So far, avoidance, but not primary prevention, of Down\u2019s syndrome is available.<\/jats:p>","DOI":"10.1098\/rstb.1988.0053","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T16:53:53Z","timestamp":1166201633000},"page":"315-324","source":"Crossref","is-referenced-by-count":9,"title":["The incidence of Down's syndrome and progress towards its reduction"],"prefix":"10.1098","volume":"319","author":[{"given":"Margareta","family":"Mikkelsen","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, John F. Kennedy Institute, 7 Gl. Landevej, DK 2600 Glostrup, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","first-page":"558","article-title":"Maternal age effect in aneuploidy: does altered embryonic selection play a role? Am.J. hum","volume":"34","author":"Ayme S.","year":"1982","journal-title":"Genet."},{"key":"p_2","unstructured":"Ayme S. Baccichetti C. Bricarelli F. D. Dallapiccola B. Lungarotti D. Mikkelsen M. & Nevin N. 1986 Factors involved in chromosomal non-disjunction. In Seventh International Congress of human genetics Berlin 1986 Abstracts part 1 p. 167."},{"key":"p_3","first-page":"531","article-title":"Maternal serum a-fetoprotein and fetal trisomy-21 in women 35 years and older: implications for a-fetoprotein screening programs. Am. J. med","volume":"26","author":"Ashwood E. R.","year":"1987","journal-title":"Genet."},{"key":"p_4","first-page":"112","article-title":"Exces de gar^ons dans la trisomie 21","volume":"22","author":"Bernheim A.","year":"1979","journal-title":"Amis Genet."},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91980-X"},{"key":"p_6","doi-asserted-by":"crossref","unstructured":"Brock D. J. H. 1984 Maternal serum a-fetoprotein as screening test for Down syndrome. 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