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With the exception of the hantaviruses, these viruses infect and are transmitted by a variety of blood-sucking arthropods (mosquitoes, phlebotomines, gnats, ticks, etc.). The viruses are responsible for infection of various vertebrate species, occasionally causing human disease, morbidity and mortality (e.g. Rift Valley fever, Crimean-Congo haemorrhagic fever, Korean haemorrhagic fever). Genetic and molecular analyses of bunyaviruses have established the coding assignments of the three viral RNA species and documented which viral gene products determine host range and virulence. Ecological studies, with molecular techniques, have provided evidence for bunyavirus evolution in nature through genetic drift (involving the accumulation of point mutations) and shift (RNA- segment reassortment).<\/jats:p>","DOI":"10.1098\/rstb.1988.0103","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T16:53:53Z","timestamp":1166201633000},"page":"463-483","source":"Crossref","is-referenced-by-count":17,"title":["Molecular and biochemical studies of the evolution, infection and transmission of insect bunyaviruses"],"prefix":"10.1098","volume":"321","author":[{"given":"David H L","family":"Bishop","sequence":"first","affiliation":[{"name":"NERC Institute of Virology, Mansfield Road, Oxford OX1 3SR, U. K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, U. S. 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