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The phenomenon of temperature- dependent sex determination (TSD) was discovered almost thirty years ago, but few advances have been made towards the elucidation of its mechanism. In the past few years substantial progress has been made in the understanding of the molecular basis of XY chromosomal (genetic) sex determination (GSD) through the discovery of SRY. It is now possible to start comparing TSD with GSD. TSD is found in some evolutionarily ancient vertebrates and has been postulated to be the ancestral process from which GSD has evolved. If this is true then the two mechanisms may share a common molecular basis. This paper details the current knowledge of GSD, our progress on the investigation of the involvement of SRY-type proteins, and finally presents some of the problems that need to be resolved to gain an understanding of the molecular basis of TSD.<\/jats:p>","DOI":"10.1098\/rstb.1995.0165","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T19:03:09Z","timestamp":1166468589000},"page":"297-304","source":"Crossref","is-referenced-by-count":22,"title":["The molecular biology of temperature-dependent sex determination"],"prefix":"10.1098","volume":"350","author":[{"given":"C. M.","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Craniofacial Development, UMDS Guy's Hospital, London Bridge, London, SE1 9RT, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Development, UMDS Guy's Hospital, London Bridge, London, SE1 9RT, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. T.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Development, UMDS Guy's Hospital, London Bridge, London, SE1 9RT, U. K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","reference":[{"key":"p_1","first-page":"425","article-title":"Sex reversal by estradiol in three reptilian orders. 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