{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:43:07Z","timestamp":1789731787003,"version":"4.0.1"},"reference-count":14,"publisher":"The Royal Society","issue":"1354","license":[{"start":{"date-parts":[[1997,6,29]],"date-time":"1997-06-29T00:00:00Z","timestamp":867542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phil. Trans. R. Soc. Lond. B"],"published-print":{"date-parts":[[1997,6,29]]},"abstract":"<jats:p>\n                    Changes in cerebral blood flow (CBF) and cerebral metabolic rates (CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ) have been used as indices for changes in neuronal activity. Near\u2013infrared spectroscopy (NIRS) can also measure cerebral haemodynamics and metabolic changes, enabling the possible use of multichannel recording of NIRS for functional optical imaging of human brain activity. Spatio\u2013temporal variations of brain regions were demonstrated during various mental tasks. Non\u2013synchronous behaviour of cerebral haemodynamics during the neuronsl activation was observed. Gender\u2013 and handedness\u2013dependent lateralization of the function between right and left hemispheres was demonstrated by simultaneous measurement using two NIR instruments during the mirror\u2013drawing task. A lack of interhemispheric integration was observed with schizophrenic patients. These observations suggest an application for NIRS in psychiatric disease management, as an addition to clinical monitoring at the bedside.\n                  <\/jats:p>\n                  <jats:p>A time\u2013resolved 64\u2013channel optical imaging system was constructed. This consisted of three picosecond laser diodes and 64 channels of TAC and CFD systems. Image reconstruction for phantom model systems was performed. Time\u2013resolved quantitative optical imaging will become real in the very near future.<\/jats:p>","DOI":"10.1098\/rstb.1997.0056","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T13:23:02Z","timestamp":1033478582000},"page":"737-742","source":"Crossref","is-referenced-by-count":76,"title":["Localized near\u2013infrared spectroscopy and functional optical imaging of brain activity"],"prefix":"10.1098","volume":"352","author":[{"given":"Mamoru","family":"Tamura","sequence":"first","affiliation":[{"name":"Biophysics Division, Research Institute for Electronic Science, Hokkaido UniversitySapporo 060Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Biophysics Division, Research Institute for Electronic Science, Hokkaido UniversitySapporo 060Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Okada","sequence":"additional","affiliation":[{"name":"Health Administration Center, Hokkaido UniversitySapporo 060Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[1997,6,29]]},"reference":[{"key":"p_1","first-page":"796","article-title":"~uantitative analysis of haemoglobin oxygenation state of brain in situ by nearinfrared spectrophotometry. ~. 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Hoshi Y. & Tamura M. 1995 Region-dependent asymmetrical or symmetrical variations in the oxygenation and hemodynamics of the brain due to different mental stimuli. ~ogniti~e Brain Res. 2 215-219.","DOI":"10.1016\/0926-6410(95)90010-1"},{"key":"p_11","first-page":"209","article-title":"REM-sleep-associated haemoglobin oxygenation in the monkey forebrain studied using near-infrared spectrophotometry. ~eurosci","volume":"129","author":"Onoe H.","year":"1991","journal-title":"Lett."},{"key":"p_12","doi-asserted-by":"crossref","unstructured":"Van der Zee P. Cope M. Arridge S. R. Essenpreis M. Edwards A. D. Wyatt J. S. McCormick D. C. Reynolds E. O. R. & Delpy D. T. 1992 Experimentally measured optical pathlengths for the adult head calf and forearm and the head of the newborn infant as a function of inter optode spacing. In Ox~gen transport to tissue vol. XIII (ed. T. K. Goldstick M. McCabe & D. J. Maguire) pp. 143-153. Plenum Press.","DOI":"10.1007\/978-1-4615-3404-4_17"},{"key":"p_13","first-page":"240","article-title":"Coupling of brain activity and cerebral blood flow-basis for functional neuroimaging. ~erebro~asc. Brain Metab","volume":"7","author":"Villringer A.","year":"1995","journal-title":"Re~."},{"key":"p_14","first-page":"101","article-title":"Near-infrared spectroscopy : a new tool to study haemodynamics changes during activation of brain function of human adults. ~eurosci","volume":"154","author":"Villringer A.","year":"1993","journal-title":"Lett."}],"container-title":["Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1997.0056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.1997.0056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:26:06Z","timestamp":1778621166000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/352\/1354\/737-742\/19056"}},"subtitle":[],"editor":[{"given":"B.","family":"Chance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"C. E.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"D. 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