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Within a few seconds after stimulation (coloured dodecahedrons) we observed a decrease in [deoxy\u2013Hb], peaking after 13 s (\u2018initial undershoot\u2019). In the subsequent 1\u20132 min, in seven out of ten subjects, [deoxy\u2013Hb] gradually returned to a plateau closer to the baseline level. After cessation of stimulation, there was a \u2018post\u2013stimulus overshoot\u2019 in the concentration of deoxyhaemoglobin. There was a statistically significant correlation between the size of the \u2018initial undershoot\u2019 and the \u2018post\u2013stimulus overshoot\u2019.<\/jats:p>\n                  <jats:p>The concentration of oxyhaemoglobin increased upon functional activation. However, in the mean across all subjects there was no initial overshoot. After approximately 19 s it reached a plateau and remained constantly elevated throughout the activation period. After cessation of activation there was a \u2018post\u2013stimulus undershoot\u2019 of oxyhaemoglobin.<\/jats:p>\n                  <jats:p>It is important to consider the time\u2013course of haemoglobin oxygenation when interpreting functional activation data, especially those data obtained with oxygenation\u2013sensitive methods, such as BOLD contrast fMRI.<\/jats:p>","DOI":"10.1098\/rstb.1997.0057","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T13:23:02Z","timestamp":1033478582000},"page":"743-750","source":"Crossref","is-referenced-by-count":53,"title":["Cerebral haemoglobin oxygenation during sustained visual stimulation \u2013 a near\u2013infrared spectroscopy study"],"prefix":"10.1098","volume":"352","author":[{"given":"H. 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