{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:16:14Z","timestamp":1778624174172,"version":"3.51.4"},"reference-count":56,"publisher":"The Royal Society","issue":"1395","license":[{"start":{"date-parts":[[2000,3,29]],"date-time":"2000-03-29T00:00:00Z","timestamp":954288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phil. Trans. R. Soc. Lond. B"],"published-print":{"date-parts":[[2000,3,29]]},"abstract":"<jats:p>\n                    Infection with the human immunodeficiency virus results in profound perturbations in immunological memory, ultimately resulting in increased susceptibility to opportunistic infections and acquired immunodeficiency syndrome (AIDS). W e have used rhesus macaques infected with the simian immunodeficiency virus (SIV) as a model to understand better the effects of AIDS virus infection on immunological memory. Acute infection with SIV resulted in significant deficits in CD4\n                    <jats:sup>+<\/jats:sup>\n                    helper responses to cytomegalovirus (CMV) as well as CMV\u2013specific cytotoxic T\u2013lymphocyte and neutralizing antibody responses. Reactivation of CMV was associated with high levels of SIV replication and suppression of both T\u2013helper and cytotoxic responses to CMV . We have also studied the effects of SIV infection on T\u2013cell turnover in non\u2013human primates. T\u2013cell turnover was evaluated using the nucleoside analogue bromodeoxyuridine (BrdU) in combination with five\u2013colour flow cytometric analysis. T cells in normal animals turned over at relatively rapid rates, with memory cells turning over more quickly than naive cells. In SIV\u2013infected animals, the labelling and elimination rates of both CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    BrdU\u2013labelled cells were increased by two\u2013 to threefold compared with normal controls. Further analysis of immunological memory in nonhuman primates should offer the opportunity to extend immunological insights from murine models to the pathogenesis and prevention of AIDS.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2000.0578","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:55:21Z","timestamp":1027713321000},"page":"381-390","source":"Crossref","is-referenced-by-count":9,"title":["Immunological memory and acquired immunodeficiency syndrome pathogenesis"],"prefix":"10.1098","volume":"355","author":[{"given":"Amitinder","family":"Kaur","sequence":"first","affiliation":[{"name":"Division of Immunology, Mew England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772\u20139102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Division of Immunology, Mew England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772\u20139102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Paul Johnson","sequence":"additional","affiliation":[{"name":"Division of Immunology, Mew England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772\u20139102, USA"},{"name":"Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2000,3,29]]},"reference":[{"key":"p_1","article-title":"T-cell homeostasis: implications in HIV infection","volume":"6","author":"Adleman L. 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