{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:23:01Z","timestamp":1778624581924,"version":"3.51.4"},"reference-count":10,"publisher":"The Royal Society","issue":"1401","license":[{"start":{"date-parts":[[2000,9,29]],"date-time":"2000-09-29T00:00:00Z","timestamp":970185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phil. Trans. R. Soc. Lond. B"],"published-print":{"date-parts":[[2000,9,29]]},"abstract":"<jats:p>\n                    Goldfish are ideal vertebrates for the study of regeneration within the peripheral and the central olfactory system. The present behavioural investigations studied the effects of bilateral lesions on the animals' ability to qualitatively discriminate two amino acids (107\n                    <jats:sup>-6<\/jats:sup>\n                    M) and their performance in two more difficult tasks: (i) rewarded amino acid applied in a lower concentration, and (ii) rewarded stimulus contaminated. A 50 and 85% reduction of the olfactory epithelium resulted in no recordable behavioural deficit. After axotomy of olfactory nerves and lateral olfactory tractotomy, fishes were anosmic for seven to ten days. Following replacement of sensory cells in the epithelium, and after regeneration of olfactory tract fibres a full functional recovery, i.e. a highly specific regeneration, was recorded. After three surgical modifications of the olfactory bulbs' position, (i) crossing olfactory tracts and bulbs, (ii) crossing tracts and turning bulbs, and (iii) turning bulbs upside down, a full functional recovery was recorded for amino-acid discrimination in a similar concentration. A permanent, and similar slight deficit was, however, found during application of different concentrations, and of contaminated stimuli when medial lateral halves of the bulb were in \u2018incorrect\u2019 position (i) and (iii), or olfactory bulbs were positioned in the vicinity of the contralateral epithelium (i) and (ii).\n                  <\/jats:p>","DOI":"10.1098\/rstb.2000.0671","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:55:43Z","timestamp":1027713343000},"page":"1219-1223","source":"Crossref","is-referenced-by-count":3,"title":["In goldfish the discriminative ability for odours persists after reduction of the olfactory epithelium, and rapidly returns after olfactory nerve axotomy and crossing bulbs"],"prefix":"10.1098","volume":"355","author":[{"given":"Hans Peter","family":"Zippel","sequence":"first","affiliation":[{"name":"Institut der Universit\u00e4t, Humboldtallee 23, 37073 G\u00f6ttingen, Germany ()"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2000,9,29]]},"reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Hansen A. Zippel H. P. Sorenson P. W. & Caprio J. 1999 Ultrastructure of the olfactory epithelium in intact axotomized and bulbectomized gold\u00a2sh Carassius auratus. Micros. Res.Technique 45 325^338.","DOI":"10.1002\/(SICI)1097-0029(19990515\/01)45:4\/5<325::AID-JEMT16>3.0.CO;2-V"},{"key":"p_2","doi-asserted-by":"crossref","unstructured":"Hudson R. Distel H. & Zippel H. P. 1990 Perceptual performance in peripheral reduced olfactory systems. In Chemosensory information processing (ed. D. Schild) pp. 259^269. Berlin: Springer.","DOI":"10.1007\/978-3-642-75127-1_17"},{"key":"p_3","doi-asserted-by":"crossref","unstructured":"Von Rekowski Ch. & Zippel. H. P. 1993 In gold\u00a2sh the qualitative discriminative ability for odors rapidly returns after bilateral nerve axotomy and lateral olfactory tract transection. Brain Res. 618 338^340.","DOI":"10.1016\/0006-8993(93)91287-3"},{"key":"p_4","unstructured":"Von Rekowski Ch. Schmilewski J. & Zippel H. P. 1994 Behavioral experiments in gold\u00a2sh con\u00a2rm amino acids as olfactory meaningful natural stimuli. Adv. Biosci. 93 491^496."},{"key":"p_5","article-title":"Regeneration in the peripheral and the central olfactory system: a review of morphological, physiological and behavioral aspects","volume":"34","author":"Zippel H. P.","year":"1993","journal-title":"J. Hirnforsch."},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00340911"},{"key":"p_7","doi-asserted-by":"crossref","unstructured":"Zippel H. P. Breipohl W. & Schoon H. 1981 Functional and morphological changes in \u00a2sh chemoreception systems following ablation of the olfactory bulbs. In Lesion-induced neuronal plasticity in sensorimotor system (ed. H. Flohr & W. Precht) pp. 377^394. Berlin: Springer.","DOI":"10.1007\/978-3-642-68074-8_33"},{"key":"p_8","doi-asserted-by":"crossref","unstructured":"Zippel H. P. Meyer D. L. & Knaust M. 1988 Peripheral and central post-lesion plasticity in the olfactory system of the gold\u00a2sh: behavior and morphology. In Post-lesion neural plasticity (ed. H. Flohr) pp. 577^591. Berlin: Springer.","DOI":"10.1007\/978-3-642-73849-4_51"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214718"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214717"}],"container-title":["Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2000.0671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2000.0671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:25:55Z","timestamp":1778621155000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/355\/1401\/1219-1223\/19723"}},"subtitle":[],"editor":[{"given":"S. P.","family":"Collin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"N. J.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2000,9,29]]},"references-count":10,"journal-issue":{"issue":"1401","published-print":{"date-parts":[[2000,9,29]]}},"alternative-id":["10.1098\/rstb.2000.0671"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2000.0671","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,29]]}}}