{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:52:58Z","timestamp":1789905178146,"version":"4.0.1"},"reference-count":74,"publisher":"The Royal Society","issue":"1405","license":[{"start":{"date-parts":[[2001,1,29]],"date-time":"2001-01-29T00:00:00Z","timestamp":980726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phil. Trans. R. Soc. Lond. B"],"published-print":{"date-parts":[[2001,1,29]]},"abstract":"<jats:p>\n                    Until recently, the molecular mechanisms of translesion DNA synthesis (TLS), a process whereby a damaged base is used as a template for continued replication, was poorly understood. This area of scientific research has, however, been revolutionized by the finding that proteins long implicated in TLS are, in fact, DNA polymerases. Members of this so\u2013called UmuC\/DinB\/Rev1\/Rad30 superfamily of polymerases have been identified in prokaryotes, eukaryotes and archaea. Biochemical studies with the highly purified polymerases reveal that some, but not all, can traverse blocking lesions in template DNA. All of them share a common feature, however, in that they exhibit low fidelity when replicating undamaged DNA. Of particular interest to us is the Rad30 subfamily of polymerases found exclusively in eukaryotes. Humans possess two Rad30 paralogs, Rad30A and Rad30B. The\n                    <jats:italic>RAD30A<\/jats:italic>\n                    gene encodes DNA polymerase \u03b7 and defects in the protein lead to the xeroderma pigmentosum variant (XP\u2013V) phenotype in humans. Very recently\n                    <jats:italic>RAD30B<\/jats:italic>\n                    has also been shown to encode a novel DNA polymerase, designated as Pol \u03b9. Based upon\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies, it appears that Pol \u03b9 has the lowest fidelity of any eukaryotic polymerase studied to date and we speculate as to the possible cellular functions of such a remarkably error\u2013prone DNA polymerase.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2000.0748","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T19:58:30Z","timestamp":1027713510000},"page":"53-60","source":"Crossref","is-referenced-by-count":59,"title":["DNA polymerase iota and related Rad30\u2013like enzymes"],"prefix":"10.1098","volume":"356","author":[{"given":"John P.","family":"McDonald","sequence":"first","affiliation":[{"name":"Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20892\u20132725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Tissier","sequence":"additional","affiliation":[{"name":"Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20892\u20132725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina G.","family":"Frank","sequence":"additional","affiliation":[{"name":"Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20892\u20132725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Iwai","sequence":"additional","affiliation":[{"name":"Biomolecular Engineering Research Institute, 6\u20132\u20133 Furuedia, Suita, Osaka 565\u20130874, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Cellular Biology, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 1\u20133 Yamada\u2013oka, Suita, Osaka 565\u20130871, Japan"},{"name":"The Institute of Physical and Chemical Research, (RIKEN) Wako\u2013shi, Saitama 351\u20130198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Woodgate","sequence":"additional","affiliation":[{"name":"Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20892\u20132725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2001,1,29]]},"reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Adams M. 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Natl Acad. Sci. USA. 83 3904^3908.","DOI":"10.1073\/pnas.83.11.3904"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.18.10767"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep13069659"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.21.13945"},{"key":"p_8","doi-asserted-by":"crossref","unstructured":"Cordonnier A. M. Lehmann A. R. & Fuchs R. P. P. 1999 Impaired translesion synthesis in xeroderma pigmentosum variant extracts. Mol. Cell. Biol. 19 2206^2211.","DOI":"10.1128\/MCB.19.3.2206"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01425.x"},{"key":"p_10","doi-asserted-by":"crossref","unstructured":"Diaz M. Velez J. Singh M. Cerny J. & Flajnik M. F. 1999 Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation. Int. Immunol. 11 825^833.","DOI":"10.1093\/intimm\/11.5.825"},{"key":"p_11","unstructured":"Friedberg E. C. Walker G. C. & Siede W. 1995 DNA repair and mutagenesis. Washington DC: American Society for Microbiology."},{"key":"p_12","doi-asserted-by":"crossref","unstructured":"Friedberg E. C. Feaver W. J. & Gerlach V. L. 2000 The many faces of DNA polymerases: strategies for mutagenesis and for mutational avoidance. roc. Natl Acad. Sci. USA 97 5681^5683.","DOI":"10.1073\/pnas.120152397"},{"key":"p_13","doi-asserted-by":"crossref","unstructured":"Gerlach V. L. Aravind L. Got ay G. Schultz R. A. Koonin E. V. & Friedberg E. C. 1999 Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV) members of the UmuC\/DinB superfamily. roc. Natl Acad. Sci. USA 96 11922^11927.","DOI":"10.1073\/pnas.96.21.11922"},{"key":"p_14","doi-asserted-by":"crossref","unstructured":"Goodman M. F. 2000 Coping ith replication `train recks' in Escherichia coli using Pol V Pol II and RecA proteins. 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