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Hippocampal excitatory synaptic transmission and plasticity are disrupted in transgenic mice overexpressing human amyloid precursor protein with early onset familial AD mutations, and in rats after exogenous application of synthetic A\u03b2 both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Recently, naturally produced soluble A\u03b2 was shown to block the persistence of long-term potentiation (LTP) in the intact hippocampus. Sub-nanomolar concentrations of oligomeric A\u03b2 were sufficient to inhibit late LTP, pointing to a possible reason for the sensitivity of hippocampus-dependent memory to impairment in the early preclinical stages of AD. Having identified the active species of A\u03b2 that can play havoc with synaptic plasticity, it is hoped that new ways of targeting early AD can be developed.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2002.1240","type":"journal-article","created":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T11:27:32Z","timestamp":1063106852000},"page":"821-828","source":"Crossref","is-referenced-by-count":154,"title":["Synaptic plasticity in animal models of early Alzheimer's disease"],"prefix":"10.1098","volume":"358","author":[{"given":"Michael J.","family":"Rowan","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Klyubin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Anwyl","sequence":"additional","affiliation":[{"name":"Department of Physiology, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2003,4,29]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(01)00007-7"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00509-5"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1101\/lm.43701"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00079-5"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1999.0276"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1255"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00132-X"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1224"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02285-5"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1038\/6374"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000401)60:1<65::AID-JNR7>3.0.CO;2-Q"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2001.4034"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199612200-00018"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199710200-00006"},{"key":"p_15","first-page":"330P","article-title":"b-amyloid produces a selective block of late-phase long-term potentiation in rat hippocampus in vivo","volume":"122","author":"Cullen W. 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