{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:42:43Z","timestamp":1789875763966,"version":"4.0.1"},"reference-count":33,"publisher":"The Royal Society","issue":"1445","license":[{"start":{"date-parts":[[2004,5,29]],"date-time":"2004-05-29T00:00:00Z","timestamp":1085788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phil. Trans. R. Soc. Lond. B"],"published-print":{"date-parts":[[2004,5,29]]},"abstract":"<jats:p>\n                    Growth factors are polypeptides that stimulate the division of certain cell types at low concentrations. Fibroblast growth factor (FGF) 7 (FGF\u20137) and its homologue FGF\u201310 act specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, FGF\u20137 and FGF\u201310 have been shown to be more than growth factors: they can protect epithelial cells from damaging effects induced, for example, by radiation and oxidative stress. Therefore, they are currently in clinical trials for the treatment of oral mucositis, a severe side\u2013effect of cancer therapy characterized by painful inflammation and ulceration of the oral epithelium. To gain insight into the mechanisms of FGF\u20137\/FGF\u201310 action in epithelial cells, we searched for genes that are regulated by these growth factors. Indeed, we identified genes that help us to explain the mechanisms that underlie the effects of FGF\u20137. Most interestingly, several genes were identified that are likely to mediate the cytoprotective effect of FGF\u20137 for epithelial cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    and possibly also in injured and diseased tissues\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1098\/rstb.2004.1464","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T17:18:53Z","timestamp":1082049533000},"page":"753-757","source":"Crossref","is-referenced-by-count":75,"title":["Fibroblast growth factors in epithelial repair and cytoprotection"],"prefix":"10.1098","volume":"359","author":[{"given":"Susanne","family":"Braun","sequence":"first","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich, H\u00f6nggerberg, CH\u20138093 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"auf dem Keller","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich, H\u00f6nggerberg, CH\u20138093 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Steiling","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich, H\u00f6nggerberg, CH\u20138093 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Werner","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, ETH Z\u00fcrich, H\u00f6nggerberg, CH\u20138093 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2004,5,29]]},"reference":[{"key":"p_1","doi-asserted-by":"crossref","unstructured":"Abraham J. A. & Klagsbrun M. 1996 Modulation of wound repair by members of the fibroblast growth factor family. In The molecular and cellular biology of wound repair (ed. R. A. F. Clark) pp. 195-248. New York: Plenum Press.","DOI":"10.1007\/978-1-4899-0185-9_6"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60305-X"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201383"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00139-3"},{"key":"p_5","first-page":"521","article-title":"Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease","volume":"149","author":"Brauchle M.","year":"1996","journal-title":"Am. J. 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Series B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2004.1464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2004.1464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:26:38Z","timestamp":1778621198000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/359\/1445\/753-757\/20404"}},"subtitle":[],"editor":[{"given":"J. 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