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The mineral apatite, which is the only significant source of phosphate on Earth, has long been thought to be problematical in this respect due to its low solubility and reactivity. However, in the last decade or so, at least two pathways have been demonstrated which would circumvent these perceived problems. In addition, recent results would seem to suggest an additional, extraterrestrial source of reactive phosphorus. It appears that the \u2018phosphorus problem\u2019 is no longer the stumbling block which it was once thought to be.<\/jats:p>","DOI":"10.1098\/rstb.2006.1901","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T12:00:00Z","timestamp":1158062400000},"page":"1743-1749","update-policy":"https:\/\/doi.org\/10.1098\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":191,"title":["Phosphorus in prebiotic chemistry"],"prefix":"10.1098","volume":"361","author":[{"given":"Alan W","family":"Schwartz","sequence":"first","affiliation":[{"name":"Radboud University NijmegenNijmegen 6500, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"e_1_3_1_2_1","unstructured":"Blum H.F Time's arrow and evolution. 1951 Princeton NJ:Princeton University Press."},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(92)90023-C"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006700512902"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11084-005-0093-9"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/378474a0"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2115-6_12"},{"key":"e_1_3_1_8_1","first-page":"91","volume-title":"Nobel symposium","author":"Gedulin B","year":"1994"},{"key":"e_1_3_1_9_1","first-page":"31","volume-title":"US geological survey bulletin","author":"Gilbert J.S","year":"1994"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006622900660"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927976"},{"key":"e_1_3_1_12_1","first-page":"479","article-title":"Phosphorus as a factor in the origin of life","volume":"43","author":"Gulick A","year":"1955","journal-title":"Am. 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