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These require very close three-dimensional matching, which determines infectious nucleant or prion activity. Evidence for nucleation processes is found widely in the organic and inorganic worlds and in the interactions between them: in the formation of amyloid fibrils; in the biochemistry of silicon; in cave formations deep in the Earth; and in outer space. Kuru in its location in Papua New Guinea has also led to an understanding of the cultural achievements of the Palaeo-Melanesians, with deep roots in human history.<\/jats:p>","DOI":"10.1098\/rstb.2008.0070","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T01:52:55Z","timestamp":1223949175000},"page":"3697-3700","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Kuru and its contribution to medicine"],"prefix":"10.1098","volume":"363","author":[{"given":"D. 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