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Neuropathological findings were compared with those seen in classical (sporadic and iatrogenic) Creutzfeldt\u2013Jakob disease (CJD) and variant CJD (vCJD). The neuropathological findings of the kuru patient showed all the stereotypical changes that define kuru, with the occurrence of prominent PrP plaques throughout the brain. Lymphoreticular tissue showed no evidence of prion colonization, suggesting that the peripheral pathogenesis of kuru is similar to that seen in classical CJD rather than vCJD. These findings now strongly suggest that the characteristic peripheral pathogenesis of vCJD is determined by prion strain type alone rather than route of infection.<\/jats:p>","DOI":"10.1098\/rstb.2008.0091","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T01:52:55Z","timestamp":1223949175000},"page":"3755-3763","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease"],"prefix":"10.1098","volume":"363","author":[{"given":"Sebastian","family":"Brandner","sequence":"first","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Whitfield","sequence":"additional","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"},{"name":"Papua New Guinea Institute of Medical ResearchPO Box 60, Goroka, EHP 441, Papua New Guinea"},{"name":"Centre for International Health, ABCRC, Shenton Park Campus, Curtin UniversityGPO Box U1987, Perth, WA 6845, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Boone","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical ResearchPO Box 60, Goroka, EHP 441, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Puwa","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical ResearchPO Box 60, Goroka, EHP 441, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"O'Malley","sequence":"additional","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M","family":"Linehan","sequence":"additional","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Joiner","sequence":"additional","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Scaravilli","sequence":"additional","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Calder","sequence":"additional","affiliation":[{"name":"MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryQueen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"P. 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