{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:50:36Z","timestamp":1790718636271,"version":"4.1.0"},"reference-count":72,"publisher":"The Royal Society","issue":"1635","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2014,2,5]]},"abstract":"<jats:p>\n                    Internal representations about the external world can be driven by the external stimuli or can be internally generated in their absence. It has been a matter of debate whether novel stimuli from the external world are instructive over the brain network to create\n                    <jats:italic>de novo<\/jats:italic>\n                    representations or, alternatively, are selecting from existing pre-representations hosted in preconfigured brain networks. The hippocampus is a brain area necessary for normal internally generated spatial\u2013temporal representations and its dysfunctions have resulted in anterograde amnesia, impaired imagining of new experiences, and hallucinations. The compressed temporal sequence of place cell activity in the rodent hippocampus serves as an animal model of internal representation of the external space. Based on our recent results on the phenomenon of novel place cell sequence preplay, we submit that the place cell sequence of a novel spatial experience is determined, in part, by a selection of a set of cellular firing sequences from a repertoire of existing temporal firing sequences in the hippocampal network. Conceptually, this indicates that novel stimuli from the external world select from their pre-representations rather than create\n                    <jats:italic>de novo<\/jats:italic>\n                    our internal representations of the world.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2012.0522","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T22:55:45Z","timestamp":1387839345000},"page":"20120522","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":75,"title":["Selection of preconfigured cell assemblies for representation of novel spatial experiences"],"prefix":"10.1098","volume":"369","author":[{"given":"George","family":"Dragoi","sequence":"first","affiliation":[{"name":"The Picower Institute for Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Tonegawa","sequence":"additional","affiliation":[{"name":"The Picower Institute for Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016823108"},{"key":"e_1_3_1_3_2","first-page":"382","volume-title":"Organization of memory","author":"Tulving E","year":"1972"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.001"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610561104"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oseo\/instance.00018020"},{"key":"e_1_3_1_7_2","volume-title":"The republic","author":"Plato","year":"1894"},{"key":"e_1_3_1_8_2","volume-title":"Critique of pure reason","author":"Kant I","year":"1781"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.20.1.11"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.53.100901.135114"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00186-6"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1974"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09081187"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.011"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90358-1"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.02.023"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1996)6:2<149::AID-HIPO6>3.0.CO;2-K"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20202"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2106"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00465-3"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.6.663"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09497.1999"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01096-6"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1825"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09633"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1961"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90423-5"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8351520"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80629-7"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437938100"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.037"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04587"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2344"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.034"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8036517"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5257.1870"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1265-08.2008"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-07-02382.1989"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.006"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.027"},{"key":"e_1_3_1_41_2","volume-title":"The organization of behavior: a neuropsychological theory","author":"Hebb DO","year":"1949"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306031110"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12112"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(78)90058-4"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-07-01951.1987"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114037"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2599"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-04090.1999"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0043158"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7878473"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6021-09.2010"},{"key":"e_1_3_1_52_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1242\/jeb.199.1.173","article-title":"Deciphering the hippocampal polyglot: the hippocampus as a path integration system","volume":"199","author":"McNaughton BL","year":"1996","journal-title":"J. Exp. Biol."},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.11.035"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3317-06.2006"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-08-02907.1989"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2005.08.011"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.99.2.195"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80773-4"},{"key":"e_1_3_1_59_2","volume-title":"The hippocampus as a cognitive map","author":"O'Keefe J","year":"1978"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3761-07.2007"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0061626"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135935"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205274"},{"key":"e_1_3_1_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2648"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08499"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3077"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215834110"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232655"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00165-X"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.100.6.852"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90183-9"},{"key":"e_1_3_1_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00071-4"},{"key":"e_1_3_1_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016051108"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2012.0522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rstb.2012.0522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2012.0522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:27:25Z","timestamp":1778621245000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/22395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":72,"journal-issue":{"issue":"1635","published-print":{"date-parts":[[2014,2,5]]}},"alternative-id":["10.1098\/rstb.2012.0522"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2012.0522","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]},"assertion":[{"value":"2014-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}