{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:28:11Z","timestamp":1791595691050,"version":"4.3.4"},"reference-count":108,"publisher":"The Royal Society","issue":"1615","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2013,4,5]]},"abstract":"<jats:p>\n                    A stress-diathesis explanatory model of suicidal behaviour has proved to be of heuristic value, and both clinical and neurobiological components can be integrated into such a model. A trait deficiency in serotonin input to the anterior cingulate and ventromedial prefrontal cortex is found in association with suicide, and more recently non-fatal suicidal behaviour, and is linked to decision-making and suicide intent by imaging and related studies\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The same neural circuitry and serotonin deficiency may contribute to impulsive aggressive traits that are part of the diathesis for suicidal behaviour and are associated with early onset mood disorders and greater risk for suicidal behaviour. Other brain areas manifest deficient serotonin input, that is, a trait related to recurrent major depressive disorder and bipolar disorder. Thus the serotonin system is involved in both the diathesis for suicidal behaviour in terms of decision-making, and to a major stressor, namely episodes of major depression.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2012.0537","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T20:55:53Z","timestamp":1361825753000},"page":"20120537","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":191,"title":["The serotonergic system in mood disorders and suicidal behaviour"],"prefix":"10.1098","volume":"368","author":[{"given":"J. John","family":"Mann","sequence":"first","affiliation":[{"name":"Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10471, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1176\/ajp.156.2.181","article-title":"Toward a clinical model of suicidal behavior in psychiatric patients","volume":"156","author":"Mann JJ","year":"1999","journal-title":"Am. J. Psychiat."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.06091522"},{"key":"e_1_3_2_4_2","first-page":"41","volume-title":"Suicide","author":"Kety SS","year":"1986"},{"key":"e_1_3_2_5_2","first-page":"S12","article-title":"Genetics of suicide in depression (Review)","volume":"60","author":"Roy A","year":"1999","journal-title":"J. Clin. Psychiat."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810250031003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.7.1075"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798006916"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi363"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30092"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32832e4bcd"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10040541"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020690"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.021"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.16.2064"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-4-37"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0593-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.06.016"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2006.04.003"},{"key":"e_1_3_2_20_2","first-page":"11","article-title":"Monoamine dysfunction and the pathophysiology and treatment of depression","volume":"59","author":"Charney DS","year":"1998","journal-title":"J. Clin. Psychiat."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005687"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90501-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.4.566"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00319.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb52359.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb16903.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(03)00050-5"},{"key":"e_1_3_2_28_2","first-page":"22","article-title":"Postmortem evidence for serotonin's role in suicide","volume":"51","author":"Stanley M","year":"1990","journal-title":"J. Clin. Psychiat."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1192\/S000712500029171X"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.01.083"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002143"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02225.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00040-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1658"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820200025003"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800150053007"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb27900.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.168.3.324"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)90633-5"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.28"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)36037-0"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb52365.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178168"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5304.1293"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2516-10.2010"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1991.0077"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.09.006"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.79"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.1.14"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000392"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00482-7"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00202-4"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03243-2"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.915"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.1.90"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.10.022"},{"key":"e_1_3_2_57_2","first-page":"499","article-title":"Serotonin2A receptor binding potential in people with aggressive and violent behaviour","volume":"33","author":"Meyer JH","year":"2008","journal-title":"J. Psychiatr. Neurosci. Jpn"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00261.x"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2116-z"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710001601"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m06879"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.6.1100"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11com07463"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2008.11.004"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06634"},{"key":"e_1_3_2_66_2","volume-title":"The Neurobiological basis of suicide","author":"Okusaga O","year":"2012"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-008-0039-4"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318268de9f"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.030"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0804-06.2006"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200204000-00012"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.164.2.248"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2008.02.002"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000949"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083968"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.026"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072290"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.006"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.01.018"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300992"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.016"},{"key":"e_1_3_2_82_2","first-page":"106","article-title":"Altered serotonin 1A binding in major depression: a [carbonyl-11C]WAY-100635 positron emission tomography study","volume":"59","author":"Parsey RV","year":"2004","journal-title":"Arch. Gen. Psychiat."},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.028"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00523-S"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03243-2"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.2.383"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(00)89046-0"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.66.3.493"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2648"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300774"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.1.52"},{"key":"e_1_3_2_92_2","article-title":"PET quantification of serotonin transporter in suicide attempters with major depressive disorder","author":"Miller JM","journal-title":"Biol. Psychiat."},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001365"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.1.48"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00533.x"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5199-05.2006"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20637"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00124-3"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00043-8"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.082"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.75"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101678"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1366"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.03.012"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00550.x"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071829"},{"key":"e_1_3_2_107_2","article-title":"The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis","author":"Miller R","year":"2012","journal-title":"Mol. Psychiat."},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0029616"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.025"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2012.0537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rstb.2012.0537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2012.0537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:25:35Z","timestamp":1778621135000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/22057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,5]]},"references-count":108,"journal-issue":{"issue":"1615","published-print":{"date-parts":[[2013,4,5]]}},"alternative-id":["10.1098\/rstb.2012.0537"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2012.0537","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,5]]},"assertion":[{"value":"2013-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}