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However, two findings challenge this view. First, new model-based tools of attention research have revealed that impaired selective attention accompanies memory deficits from early pre-dementia AD stages on. Second, very early distributed lesions of lateral parietal networks may cause these attention deficits by disrupting brain mechanisms underlying attentional biased competition. We suggest that memory and attention impairments might indicate disturbances of a common underlying neurocognitive mechanism. We propose a unifying account of impaired neural interactions within and across brain networks involved in attention and memory inspired by the biased competition principle. We specify this account at two levels of analysis: at the computational level, the selective competition of representations during both perception and memory is biased by AD-induced lesions; at the large-scale brain level, integration within and across intrinsic brain networks, which overlap in parietal and temporal lobes, is disrupted. This account integrates a large amount of previously unrelated findings of changed behaviour and brain networks and favours a brain mechanism-centred view on AD.<\/jats:p>","DOI":"10.1098\/rstb.2013.0062","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T20:41:10Z","timestamp":1378759270000},"page":"20130062","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["A biased competition account of attention and memory in Alzheimer's disease"],"prefix":"10.1098","volume":"368","author":[{"given":"Kathrin","family":"Finke","sequence":"first","affiliation":[{"name":"Department of Psychology, General and Experimental Psychology\/Neuro-cognitive Psychology, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Department of Psychology, Neuro-Cognitive Psychology, Bielefeld University, Bielefeld, Germany"},{"name":"Center for Interdisciplinary Research, Bielefeld University, Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Brain and Cognition Laboratory, Oxford University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bublak","sequence":"additional","affiliation":[{"name":"Hans-Berger Department of Neurology, Neuropsychology Unit, University Hospital Jena, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sorg","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Neuroradiology, Nuclear Medicine, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2013,10,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1991.tb00661.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68542-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.397"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70223-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.52"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162844"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.028"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr066"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl178"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260969.94695.56"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000228230.26044.a4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.09.027"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)80033-7"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708803104"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.003"},{"key":"e_1_3_3_30_2","article-title":"Resting state functional connectivity in preclinical Alzheimer's disease","author":"Sheline YI","journal-title":"Biol. 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