{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:25:01Z","timestamp":1778624701167,"version":"3.51.4"},"reference-count":50,"publisher":"The Royal Society","issue":"1628","license":[{"start":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T00:00:00Z","timestamp":1382140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2013,10,19]]},"abstract":"<jats:p>When searching for an object, we usually avoid items that are visually different from the target and objects or places that have been searched already. Previous studies have shown that neural activity in the lateral intraparietal area (LIP) can be used to guide this behaviour; responses to task irrelevant stimuli or to stimuli that have been fixated previously in the trial are reduced compared with responses to potential targets. Here, we test the hypothesis that these reduced responses have a different genesis. Two animals were trained on a visual foraging task, in which they had to find a target among a number of physically identical potential targets (T) and task irrelevant distractors. We recorded neural activity and local field potentials (LFPs) in LIP while the animals performed the task. We found that LFP power was similar for potential targets and distractors but was greater in the alpha and low beta bands when a previously fixated T was in the response field. We interpret these data to suggest that the reduced single-unit response to distractors is a bottom-up feed-forward result of processing in earlier areas and the reduced response to previously fixated Ts is a result of active top-down suppression.<\/jats:p>","DOI":"10.1098\/rstb.2013.0069","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T20:41:10Z","timestamp":1378759270000},"page":"20130069","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Evidence for differential top-down and bottom-up suppression in posterior parietal cortex"],"prefix":"10.1098","volume":"368","author":[{"given":"Koorosh","family":"Mirpour","sequence":"first","affiliation":[{"name":"Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Bisley","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA"},{"name":"Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA"},{"name":"Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA"},{"name":"Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2013,10,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.017"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-152823"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.02.003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062012-170249"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1557-8"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.192666"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.4.2019"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1461-1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00413.2006"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00688.2009"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5074-05.2006"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1779-06.2006"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060158"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/334430a0"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2012.03.022"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-10-03963.2003"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"e_1_3_4_19_2","first-page":"1","article-title":"A UNIX-based multiple process system for real-time data acquisition and control","volume":"2","author":"Hays AV","year":"1982","journal-title":"WESCON Conf. Proc."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.06.020"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120763109"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.66.3.1095"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00397.2010"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00764-5"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109676"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn890"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00221"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2008-12.2012"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01452-2"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138071"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1055465"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2006.06.003"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5199-10.2011"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00323.2012"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0875-06.2006"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077395"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.013"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0160-10.2010"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1734"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215402109"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2009.11.013"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1109\/34.730558"},{"key":"e_1_3_4_43_2","first-page":"219","article-title":"Shifts in selective visual attention: towards the underlying neural circuitry","volume":"4","author":"Koch C","year":"1985","journal-title":"Hum. Neurobiol."},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2006.10.001"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.002"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.112.2.291"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.12.006"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1586-2"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00867.2011"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.1.37"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.029"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2013.0069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rstb.2013.0069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2013.0069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:27:26Z","timestamp":1778621246000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/22317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,19]]},"references-count":50,"journal-issue":{"issue":"1628","published-print":{"date-parts":[[2013,10,19]]}},"alternative-id":["10.1098\/rstb.2013.0069"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2013.0069","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,19]]},"assertion":[{"value":"2013-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}