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One promising class of new interventions under development involves the heritable modification of the mosquito by insertion of novel genes into the nucleus or of\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    endosymbionts into the cytoplasm. Once released into a target population, these modifications can act to reduce one or more components of the mosquito population's vectorial capacity (e.g. the number of female mosquitoes, their longevity or their ability to support development and transmission of the pathogen). Some of the modifications under development are designed to be self-limiting, in that they will tend to disappear over time in the absence of recurrent releases (and hence are similar to the sterile insect technique, SIT), whereas other modifications are designed to be self-sustaining, spreading through populations even after releases stop (and hence are similar to traditional biological control). Several successful field trials have now been performed with\n                    <jats:italic>Aedes<\/jats:italic>\n                    mosquitoes, and such trials are helping to define the appropriate developmental pathway for this new class of intervention.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2013.0432","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T21:53:57Z","timestamp":1399931637000},"page":"20130432","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":204,"title":["Heritable strategies for controlling insect vectors of disease"],"prefix":"10.1098","volume":"369","author":[{"given":"Austin","family":"Burt","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Imperial College London, Silwood Park, Ascot, Berks SL5 7PY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"World malaria report 2012","author":"WHO","year":"2012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000406"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2009.02287.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61655-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.62.081307.163005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1101"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.10.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409001318"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70254-3"},{"key":"e_1_3_2_11_2","unstructured":"RBM (Roll Back Malaria). 2008 Global malaria action plan . 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