{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:47:26Z","timestamp":1791085646846,"version":"4.1.0"},"reference-count":42,"publisher":"The Royal Society","issue":"1645","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2014,6,19]]},"abstract":"<jats:p>\n                    A combination of methods, including mathematical model construction, demographic plus epidemiological data analysis and parameter estimation, are used to examine whether mass drug administration (MDA) alone can eliminate the transmission of soil-transmitted helminths (STHs). Numerical analyses suggest that in all but low transmission settings (as defined by the magnitude of the basic reproductive number,\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    ), the treatment of pre-school-aged children (pre-SAC) and school-aged children (SAC) is unlikely to drive transmission to a level where the parasites cannot persist. High levels of coverage (defined as the fraction of an age group effectively treated) are required in pre-SAC, SAC and adults, if MDA is to drive the parasite below the breakpoint under which transmission is eliminated. Long-term solutions to controlling helminth infections lie in concomitantly improving the quality of the water supply, sanitation and hygiene (WASH). MDA, however, is a very cost-effective tool in long-term control given that most drugs are donated free by the pharmaceutical industry for poor regions of the world. WASH interventions, by lowering the basic reproductive number, can facilitate the ability of MDA to interrupt transmission.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2013.0435","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T21:53:57Z","timestamp":1399931637000},"page":"20130435","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":174,"title":["The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths"],"prefix":"10.1098","volume":"369","author":[{"given":"Roy","family":"Anderson","sequence":"first","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, St Marys Campus, Norfolk Place, London W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Truscott","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, St Marys Campus, Norfolk Place, London W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Deirdre","family":"Hollingsworth","sequence":"additional","affiliation":[{"name":"Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK"},{"name":"School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK"},{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization. 2013 Preventive Chemotherapy Database Soil-transmitted helminthiases. See http:\/\/www.who.int\/neglected_diseases\/preventive_chemotherapy\/sth\/en\/index.html (20 May 2013)."},{"key":"e_1_3_2_3_2","unstructured":"Uniting to Combat NTDs. 2013 From promises to progress: the first report on the London Declaration on NTDs. See http:\/\/unitingtocombatntds.org\/resource\/promises-progress-first-report-london-declaration-ntds."},{"key":"e_1_3_2_4_2","unstructured":"WHO. 2013 Executive Board recommendations on neglected tropical diseases. 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