{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:22:34Z","timestamp":1778624554965,"version":"3.51.4"},"reference-count":44,"publisher":"The Royal Society","issue":"1646","license":[{"start":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T00:00:00Z","timestamp":1404518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2014,7,5]]},"abstract":"<jats:p>\n                    Autophagy is a well-conserved catabolic process, involving the degradation of a cell's own components through the lysosomal\/vacuolar machinery. Autophagy is typically induced by nutrient starvation and has a role in nutrient recycling, cellular differentiation, degradation and programmed cell death. Another common response in eukaryotes is the extension of lifespan through dietary restriction (DR). We studied a link between DR and autophagy in the filamentous fungus\n                    <jats:italic>Podospora anserina<\/jats:italic>\n                    , a multicellular model organism for ageing studies and mitochondrial deterioration. While both carbon and nitrogen restriction extends lifespan in\n                    <jats:italic>P. anserina,<\/jats:italic>\n                    the size of the effect varied with the amount and type of restricted nutrient. Natural genetic variation for the DR response exists. Whereas a switch to carbon restriction up to halfway through the lifetime resulted in extreme lifespan extension for wild-type\n                    <jats:italic>P. anserina<\/jats:italic>\n                    , all autophagy-deficient strains had a shorter time window in which ageing could be delayed by DR. Under nitrogen limitation, only Pa\n                    <jats:italic>Atg1<\/jats:italic>\n                    and Pa\n                    <jats:italic>Atg8<\/jats:italic>\n                    mediate the effect of lifespan extension; the other autophagy-deficient mutants Pa\n                    <jats:italic>PspA<\/jats:italic>\n                    and Pa\n                    <jats:italic>Uth1<\/jats:italic>\n                    had a similar response as wild-type. Our results thus show that the ageing process impinges on the DR response and that this at least in part involves the genetic regulation of autophagy.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2013.0447","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T21:32:47Z","timestamp":1401139967000},"page":"20130447","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Does autophagy mediate age-dependent effect of dietary restriction responses in the filamentous fungus\n                    <i>Podospora anserina<\/i>\n                    ?"],"prefix":"10.1098","volume":"369","author":[{"given":"Anne D.","family":"van Diepeningen","sequence":"first","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"},{"name":"CBS-KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00ebl J. P.","family":"Engelmoer","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"},{"name":"Department of Ecological Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Boelelaan 1085, 1081 HV Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole H.","family":"Sellem","sequence":"additional","affiliation":[{"name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, CNRS, UPR2167, 91198 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne H. E. W.","family":"Huberts","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Marijke","family":"Slakhorst","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Sainsard-Chanet","sequence":"additional","affiliation":[{"name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, CNRS, UPR2167, 91198 Gif-sur-Yvette, France"},{"name":"Universit\u00e9 Paris-Sud, 91405 Orsay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas J.","family":"Zwaan","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf F.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons J. M.","family":"Debets","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Plant Sciences, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2014,7,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb05658.x"},{"key":"e_1_3_3_3_2","volume-title":"The retardation of aging and disease by dietary restriction","author":"Weindruch RH","year":"1988"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2006.02.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35041700"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2000.tb00076.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030223"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.7124"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3440109"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1052903"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00099-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099993"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040024"},{"key":"e_1_3_3_15_2","first-page":"56","article-title":"Protoplasmic incompatibility: possible involvement of proteolytic enzymes","volume":"235","author":"B\u00e9gueret J","year":"1972","journal-title":"Nature"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.2.238-246.2003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03208.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.11.1765-1774.2005"},{"key":"e_1_3_3_19_2","first-page":"1106","article-title":"Sur la long\u00e9vit\u00e9 des souches de P. anserine","volume":"237","author":"Rizet G","year":"1953","journal-title":"CR. Acad. Sci."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2012.05569.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004380050763"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200800005"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.26.120192.002031"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010000816277"},{"key":"e_1_3_3_25_2","first-page":"215","article-title":"Senescence in Podospora anserina","volume":"20","author":"Tudzynski P","year":"1980","journal-title":"Gerontologist"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.03.005"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01435254"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90126-9"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00268860"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02221555"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2004.04.007"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2009.12.002"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.01.002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsyr.2004.05.001"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406960200"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-008-0180-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.021"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2006.09.005"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08619"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002940050395"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1655"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03311.x"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4034"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2003.10.015"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1247904"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2013.0447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rstb.2013.0447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2013.0447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:25:41Z","timestamp":1778621141000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/57967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,5]]},"references-count":44,"journal-issue":{"issue":"1646","published-print":{"date-parts":[[2014,7,5]]}},"alternative-id":["10.1098\/rstb.2013.0447"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2013.0447","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,5]]},"assertion":[{"value":"2014-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}