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For Engrailed, we discuss its function in the cell-autonomous regulation of ventral midbrain dopaminergic neuron survival and physiology and in the non-cell-autonomous maintenance of axons. For Otx2, we describe how the protein is expressed in the choroid plexus and transported into cortical parvalbumin cells where it regulates plasticity in the visual cortex. These two examples illustrate how the understanding of HP postnatal and adult functions, including signalling functions, may lead to the identification of disease-associated genetic pathways and to the development of original therapeutic strategies.<\/jats:p>","DOI":"10.1098\/rstb.2013.0518","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T21:16:11Z","timestamp":1408396571000},"page":"20130518","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Postnatal signalling with homeoprotein transcription factors"],"prefix":"10.1098","volume":"369","author":[{"given":"Alain","family":"Prochiantz","sequence":"first","affiliation":[{"name":"CIRB, CNRS UMR 7241\/INSERM U1050, College de France, 11 place Marcelin Berthelot, Paris Cedex 05 75231, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Fuchs","sequence":"additional","affiliation":[{"name":"CIRB, CNRS UMR 7241\/INSERM U1050, College de France, 11 place Marcelin Berthelot, Paris Cedex 05 75231, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel A.","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"CIRB, CNRS UMR 7241\/INSERM U1050, College de France, 11 place Marcelin Berthelot, Paris Cedex 05 75231, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2884726"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2.12b.1736"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(94)90132-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0304-189"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006577"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/379694a0"},{"key":"e_1_3_3_8_2","first-page":"1275","article-title":"Homeodomain proteins and eukaryotic translation initiation factor 4E (eIF4E): an unexpected relationship","volume":"20","author":"Topisirovic I","year":"2005","journal-title":"Histol. 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