{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:05:21Z","timestamp":1789974321065,"version":"4.0.1"},"reference-count":94,"publisher":"The Royal Society","issue":"1663","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2015,3,5]]},"abstract":"<jats:p>\n                    Evolutionary trade-offs required for bipedalism and brain expansion influence the pregnancy rise in uterine artery (UtA) blood flow and, in turn, reproductive success. We consider the importance of UtA blood flow by reviewing its determinants and presenting data from 191 normotensive (normal,\n                    <jats:italic>n<\/jats:italic>\n                    = 125) or hypertensive (preeclampsia (PE) or gestational hypertension (GH),\n                    <jats:italic>n<\/jats:italic>\n                    = 29) Andean residents of very high (4100\u20134300 m) or low altitude (400 m,\n                    <jats:italic>n<\/jats:italic>\n                    = 37). Prior studies show that UtA blood flow is reduced in pregnancies with intrauterine growth restriction (IUGR) but whether the IUGR is due to resultant fetal hypoxia is unclear. We found higher UtA blood flow and Doppler indices of fetal hypoxia in normotensive women at high versus low altitude but similar fetal growth. UtA blood flow was markedly lower in early-onset PE versus normal high-altitude women, and their fetuses more hypoxic as indicated by lower fetal heart rate, Doppler indices and greater IUGR. We concluded that, despite greater fetal hypoxia, fetal growth was well defended by higher UtA blood flows in normal Andeans at high altitude but when compounded by lower UtA blood flow in early-onset PE, exaggerated fetal hypoxia caused the fetus to respond by decreasing cardiac output and redistributing blood flow to help maintain brain development at the expense of growth elsewhere. We speculate that UtA blood flow is not only an important supply line but also a trigger for stimulating the metabolic and other processes regulating feto-placental metabolism and growth. Studies using the natural laboratory of high altitude are valuable for identifying the physiological and genetic mechanisms involved in human reproductive success.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2014.0068","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T22:59:03Z","timestamp":1421708343000},"page":"20140068","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":112,"title":["Uterine artery blood flow, fetal hypoxia and fetal growth"],"prefix":"10.1098","volume":"370","author":[{"given":"Vaughn A.","family":"Browne","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of Colorado Denver, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen G.","family":"Julian","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Toledo-Jaldin","sequence":"additional","affiliation":[{"name":"Instituto Boliviano de Biolog\u00eda de Altura, La Paz, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darleen","family":"Cioffi-Ragan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Vargas","sequence":"additional","affiliation":[{"name":"Instituto Boliviano de Biolog\u00eda de Altura, La Paz, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna G.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0069"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0065"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0067"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0070"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0071"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90637-1"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.02.009"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.05.007"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.10151"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12080"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.12.009"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod17.1.148"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117187"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90139-8"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/640715"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00217.x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90149-4"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml016"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.07.032"},{"key":"e_1_3_4_21_2","first-page":"287","article-title":"Review of studies in human pregnancy of uterine and umbilical blood flows","volume":"17","author":"Battaglia FC","year":"2013","journal-title":"Dev. 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