{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:19:33Z","timestamp":1778624373904,"version":"3.51.4"},"reference-count":42,"publisher":"The Royal Society","issue":"1671","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2015,6,19]]},"abstract":"<jats:p>Considerable variation in antibody response (AR) was observed among recipients of an injectable typhoid vaccine and an oral cholera vaccine. We sought to find whether polymorphisms in genes of the immune system, both innate and adaptive, were associated with the observed variation in response. For both vaccines, we were able to discover and validate several polymorphisms that were significantly associated with immune response. For the typhoid vaccines, these polymorphisms were on genes that belonged to pathways of polysaccharide recognition, signal transduction, inhibition of T-cell proliferation, pro-inflammatory signalling and eventual production of antimicrobial peptides. For the cholera vaccine, the pathways included epithelial barrier integrity, intestinal homeostasis and leucocyte recruitment. Even though traditional wisdom indicates that both vaccines should act as T-cell-independent antigens, our findings reveal that the vaccines induce AR using different pathways.<\/jats:p>","DOI":"10.1098\/rstb.2014.0142","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T20:41:03Z","timestamp":1431376863000},"page":"20140142","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Genomics of immune response to typhoid and cholera vaccines"],"prefix":"10.1098","volume":"370","author":[{"given":"Partha P.","family":"Majumder","sequence":"first","affiliation":[{"name":"National Institute of Biomedical Genomics, Kalyani, West Bengal 741251, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"125","article-title":"Update: mumps outbreak\u2014New York and New Jersey, June 2009\u2013January 2010","volume":"59","author":"Centers for Disease Contol and Prevention","year":"2010","journal-title":"MMWR"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0032"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.01.048"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000257454.74513.07"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364051"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00468-0"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082292"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00131-10"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.01.063"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2014.5017a.abstract"},{"issue":"1","key":"e_1_3_5_12_2","first-page":"898","article-title":"Polymorphisms in HLA-DPB1 are associated with differences in rubella virus-specific humoral immunity after vaccination","volume":"211","author":"Lambert ND","year":"2014","journal-title":"J. Infect. Dis"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2013.18"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-7-12"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1688"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.2.495"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1133"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.5067"},{"key":"e_1_3_5_19_2","first-page":"201","article-title":"Genetic variation in the response to vaccination","volume":"10","author":"Kimman TG","year":"2007","journal-title":"Community Genet."},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.4.4.5824"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807521"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.00607.x"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920306778017972"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01971520009349541"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00354-09"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/319501"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11568-010-9134-1"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.278"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm012"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255904"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.2741\/1554"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000489"},{"key":"e_1_3_5_36_2","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.4049\/jimmunol.163.12.6718","article-title":"Expression and regulation of the human b-defensins hBD1 and hBD2 in intestinal epithelium","volume":"163","author":"O'Neil DA","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00208.2011"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007806"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2928"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00296-3"},{"key":"e_1_3_5_41_2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4049\/jimmunol.162.2.939","article-title":"Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo","volume":"162","author":"Van der Laan LJW","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204494200"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.99"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2014.0142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rstb.2014.0142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2014.0142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:23:13Z","timestamp":1778620993000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/22605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,19]]},"references-count":42,"journal-issue":{"issue":"1671","published-print":{"date-parts":[[2015,6,19]]}},"alternative-id":["10.1098\/rstb.2014.0142"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2014.0142","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,19]]},"assertion":[{"value":"2015-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}