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Traditionally, highly common bacterial respiratory tract infections, including otitis media and pneumonia, were thought to be caused by a limited number of pathogens including\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    and\n                    <jats:italic>Haemophilus influenzae<\/jats:italic>\n                    . However, these pathogens are also frequently observed commensal residents of the upper respiratory tract (URT) and form\u2014together with harmless commensal bacteria, viruses and fungi\u2014intricate ecological networks, collectively known as the \u2018microbiome\u2019. Analogous to the gut microbiome, the respiratory microbiome at equilibrium is thought to be beneficial to the host by priming the immune system and providing colonization resistance, while an imbalanced ecosystem might predispose to bacterial overgrowth and development of respiratory infections. We postulate that specific ecological perturbations of the bacterial communities in the URT can occur in response to various lifestyle or environmental effectors, leading to diminished colonization resistance, loss of containment of newly acquired or resident pathogens, preluding bacterial overgrowth, ultimately resulting in local or systemic bacterial infections. Here, we review the current body of literature regarding niche-specific upper respiratory microbiota profiles within human hosts and the changes occurring within these profiles that are associated with respiratory infections.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2014.0294","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T20:41:17Z","timestamp":1436215277000},"page":"20140294","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":246,"title":["The role of the local microbial ecosystem in respiratory health and disease"],"prefix":"10.1098","volume":"370","author":[{"given":"Wouter A. 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