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Trans. R. Soc. B"],"published-print":{"date-parts":[[2016,12,5]]},"abstract":"<jats:p>\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene clusters (BGCs) producing bioactive small molecules (often referred to as secondary metabolites or natural products) that provide growth advantages to the fungus dependent on environment. Here we summarize the current knowledge of these BGCs\u201418 of which can be named to product\n                    <jats:italic>\u2014<\/jats:italic>\n                    their expression profiles\n                    <jats:italic>in vivo<\/jats:italic>\n                    , and which BGCs may enhance virulence of this opportunistic human pathogen. Furthermore, we find extensive evidence for the presence of many of these BGCs, or similar BGCs, in distantly related genera including the emerging pathogen\n                    <jats:italic>Pseudogymnoascus destructans<\/jats:italic>\n                    , the causative agent of white-nose syndrome in bats, and suggest such BGCs may be predictive of pathogenic potential in other fungi.\n                  <\/jats:p>\n                  <jats:p>This article is part of the themed issue \u2018Tackling emerging fungal threats to animal health, food security and ecosystem resilience\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2016.0023","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T21:18:37Z","timestamp":1477343917000},"page":"20160023","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":98,"title":["Secondary metabolite arsenal of an opportunistic pathogenic fungus"],"prefix":"10.1098","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7748-1920","authenticated-orcid":false,"given":"Elaine","family":"Bignell","sequence":"first","affiliation":[{"name":"Manchester Fungal Infection Group, Institute of Inflammation and Repair, 2.24 Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Cairns","sequence":"additional","affiliation":[{"name":"Department of Applied and Molecular Microbiology, Institute of Biotechnology, Berlin University of Technology, Gustav-Meyer-Allee 25, 13355 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Throckmorton","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Nierman","sequence":"additional","affiliation":[{"name":"The J. 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