{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:23:56Z","timestamp":1778624636913,"version":"3.51.4"},"reference-count":49,"publisher":"The Royal Society","issue":"1718","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"Brain-Science Institute of The Johns Hopkins University"},{"name":"The Johns Hopkins Medicine Discovery Fund"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2017,4,19]]},"abstract":"<jats:p>\n                    A fundamental challenge to the brain is how to prevent intrusive movements when quiet is needed. Unwanted limb movements such as tremor impair fine motor control and unwanted eye drifts such as nystagmus impair vision. A stable platform is also necessary to launch accurate movements. Accordingly, nature has designed control systems with agonist (excitation) and antagonist (inhibition) muscle pairs functioning in push\u2013pull, around a steady level of balanced tonic activity, the\n                    <jats:italic>set-point<\/jats:italic>\n                    . Sensory information can be organized similarly, as in the vestibulo-ocular reflex, which generates eye movements that compensate for head movements. The semicircular canals, working in coplanar pairs, one in each labyrinth, are reciprocally excited and inhibited as they transduce head rotations. The relative change in activity is relayed to the vestibular nuclei, which operate around a set-point of stable balanced activity. When a pathological imbalance occurs, producing unwanted nystagmus without head movement, an adaptive mechanism restores the proper set-point and eliminates the nystagmus. Here we used 90 min of continuous 7 T magnetic field labyrinthine stimulation (MVS) in normal humans to produce sustained nystagmus simulating vestibular imbalance. We identified multiple time-scale processes towards a new zero set-point showing that MVS is an excellent paradigm to investigate the neurobiology of set-point adaptation.\n                  <\/jats:p>\n                  <jats:p>This article is part of the themed issue \u2018Movement suppression: brain mechanisms for stopping and stillness\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2016.0199","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T20:10:18Z","timestamp":1488226218000},"page":"20160199","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Ocular stability and set-point adaptation"],"prefix":"10.1098","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-2494","authenticated-orcid":false,"given":"D. S.","family":"Zee","sequence":"first","affiliation":[{"name":"Department of Neurology, Johns Hopkins Hospital, 600 N. 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