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Trans. R. Soc. B"],"published-print":{"date-parts":[[2020,8,31]]},"abstract":"<jats:p>\n                    Studies assessing the predictability of evolution typically focus on short-term adaptation within populations or the repeatability of change among lineages. A missing consideration in speciation research is to determine whether natural selection predictably transforms standing genetic variation within populations into differences between species. Here, we test whether and how host-related selection on diapause timing associates with genome-wide differentiation during ecological speciation by comparing ancestral hawthorn and newly formed apple-infesting host races of\n                    <jats:italic>Rhagoletis pomonella<\/jats:italic>\n                    to their sibling species\n                    <jats:italic>Rhagoletis mendax<\/jats:italic>\n                    that attacks blueberries. The associations of 57 857 single nucleotide polymorphisms in a diapause genome-wide-association study (GWAS) on the hawthorn race strongly predicted the direction and magnitude of genomic divergence among the three fly populations at a field site in Fennville, MI, USA. The apple race and\n                    <jats:italic>R. mendax<\/jats:italic>\n                    show parallel changes in the frequencies of putative inversions on three chromosomes associated with the earlier fruiting times of apples and blueberries compared to hawthorns. A diapause GWAS on\n                    <jats:italic>R. mendax<\/jats:italic>\n                    revealed compensatory changes throughout the genome accounting for the earlier eclosion of blueberry, but not apple flies. Thus, a degree of predictability, although not complete, exists in the genomics of diapause across the ecological speciation continuum in\n                    <jats:italic>Rhagoletis<\/jats:italic>\n                    . The generality of this result is placed in the context of other similar systems.\n                  <\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018Towards the completion of speciation: the evolution of reproductive isolation beyond the first barriers'.<\/jats:p>","DOI":"10.1098\/rstb.2019.0534","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T19:05:36Z","timestamp":1594580736000},"page":"20190534","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Can the genomics of ecological speciation be predicted across the divergence continuum from host races to species? A case study in\n                    <i>Rhagoletis<\/i>"],"prefix":"10.1098","volume":"375","author":[{"given":"Peter J.","family":"Meyers","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-6590","authenticated-orcid":true,"given":"Meredith M.","family":"Doellman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Ragland","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Environmental Change Initiative, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Department of Integrative Biology, University of Colorado Denver, Denver, CO 80217, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9301-6153","authenticated-orcid":true,"given":"Glen R.","family":"Hood","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P.","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Department of Biosciences, Rice University, Houston, TX 77005, USA"},{"name":"Advanced Diagnostics and Therapeutics Initiative, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H. 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