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Trans. R. Soc. B"],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:p>\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    mosquitoes carrying the\n                    <jats:italic>w<\/jats:italic>\n                    AlbB\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    strain show a reduced capacity to transmit dengue virus.\n                    <jats:italic>w<\/jats:italic>\n                    AlbB has been introduced into wild\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    populations in several field sites in Kuala Lumpur, Malaysia, where it has persisted at high frequency for more than 2 years and significantly reduced dengue incidence. Although these encouraging results indicate that\n                    <jats:italic>w<\/jats:italic>\n                    AlbB releases can be an effective dengue control strategy, the long-term success depends on\n                    <jats:italic>w<\/jats:italic>\n                    AlbB maintaining high population frequencies and virus transmission inhibition, and both could be compromised by\n                    <jats:italic>Wolbachia\u2013<\/jats:italic>\n                    host coevolution in the field. Here,\n                    <jats:italic>w<\/jats:italic>\n                    AlbB-carrying\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    collected from the field 20 months after the cessation of releases showed no reduction in\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    density or tissue distribution changes compared to a\n                    <jats:italic>w<\/jats:italic>\n                    AlbB laboratory colony. The\n                    <jats:italic>w<\/jats:italic>\n                    AlbB strain continued to induce complete unidirectional cytoplasmic incompatibility, showed perfect maternal transmission under laboratory conditions, and retained its capacity to inhibit dengue. Additionally, a field-collected\n                    <jats:italic>w<\/jats:italic>\n                    AlbB line was challenged with Malaysian dengue patient blood, and showed significant blocking of virus dissemination to the salivary glands. These results indicate that\n                    <jats:italic>w<\/jats:italic>\n                    AlbB continues to inhibit currently circulating strains of dengue in field populations of\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    , and provides additional support for the continued scale-up of\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    wAlbB releases for dengue control.\n                  <\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018Novel control strategies for mosquito-borne diseases\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2019.0809","type":"journal-article","created":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T19:05:25Z","timestamp":1609095925000},"page":"20190809","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["<i>Wolbachia<\/i>\n                    strain\n                    <i>w<\/i>\n                    AlbB maintains high density and dengue inhibition following introduction into a field population of\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1098","volume":"376","author":[{"given":"Noor Afizah","family":"Ahmad","sequence":"first","affiliation":[{"name":"Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Vittoria","family":"Mancini","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Ant","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8210-2921","authenticated-orcid":true,"given":"Julien","family":"Martinez","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazali M. 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