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Trans. R. Soc. B"],"published-print":{"date-parts":[[2023,6,19]]},"abstract":"<jats:p>\n                    Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -activated K\n                    <jats:sup>+<\/jats:sup>\n                    channels are critical to cellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis and excitability; they couple intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and membrane voltage change. Of these, the small, 4\u201314 pS, conductance SK channels include three,\n                    <jats:italic>KCNN1-3<\/jats:italic>\n                    encoded, SK1\/KCa2.1, SK2\/KCa2.2 and SK3\/KCa2.3, channel subtypes with characteristic, EC\n                    <jats:sub>50<\/jats:sub>\n                    \u223c 10 nM, 40 pM, 1 nM, apamin sensitivities. All SK channels, particularly SK2 channels, are expressed in atrial, ventricular and conducting system cardiomyocytes. Pharmacological and genetic modification results have suggested that SK channel block or knockout prolonged action potential durations (APDs) and effective refractory periods (ERPs) particularly in atrial, but also in ventricular, and sinoatrial, atrioventricular node and Purkinje myocytes, correspondingly affect arrhythmic tendency. Additionally, mitochondrial SK channels may decrease mitochondrial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overload and reactive oxygen species generation. SK channels show low voltage but marked Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dependences (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u223c 300\u2013500 nM) reflecting their \u03b1-subunit calmodulin (CaM) binding domains, through which they may be activated by voltage-gated or ryanodine-receptor Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel activity. SK function also depends upon complex trafficking and expression processes and associations with other ion channels or subunits from different SK subtypes. Atrial and ventricular clinical arrhythmogenesis may follow both increased or decreased SK expression through decreased or increased APD correspondingly accelerating and stabilizing re-entrant rotors or increasing incidences of triggered activity.\n                  <\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018The heartbeat: its molecular basis and physiological mechanisms\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2022.0171","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T02:39:17Z","timestamp":1682908757000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications"],"prefix":"10.1098","volume":"378","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of China"},{"name":"Department of Cardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandi","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of 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